Temperature-dependent expression of the chromosomal -lactamase gene in a strain of Free

Abstract

Summary.

A strain of (3-Post) was resistant to cefsulodin and ceftazidime at 37°C but sensitive at 20°C. Resistance was mediated by chromosomally-encoded lactamase which was synthesised at a high level during growth above 30°C but at a low, inducible level during growth below 27°C.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-24-3-263
1987-11-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jmm/24/3/medmicro-24-3-263.html?itemId=/content/journal/jmm/10.1099/00222615-24-3-263&mimeType=html&fmt=ahah

References

  1. Ambler R P. 1980; The structure of β-lactamases. Philosophical Transactions of the Royal Society of London Series B 289:321–331
    [Google Scholar]
  2. Anwar H, Lambert P A, Brown M R W. 1983; Effect of divalent metal ions on the production of outer membrane protein H2 in mucoid and non-mucoid strains of Pseudomonas aeruginosa . FEMS Microbiology Letters 16:247–250
    [Google Scholar]
  3. Berks M. 1977; Studies on β-lactamases from Pseudomonas aeruginosa . DPhil Thesis, University of Oxford
    [Google Scholar]
  4. Hewinson R G, Slack M P E, Nichols W W. 1985; A quantitative study of beta-lactamase-mediated trapping vs hydrolysis in cefsulodin-resistant Pseudomonas aeruginosa . Ishigami J. Recent advances in chemotherapy, antimicrobial section University of Tokyo Press; Tokyo:365–366
    [Google Scholar]
  5. Jaurin B, Grundström T. 1981; ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of β-lactamases of the penicillinase type. Proceedings of the National Academy of Sciences of the USA 78:4897–4901
    [Google Scholar]
  6. King A, Shannon K, Eykyn S, Phillips I. 1983; Reduced sensitivity to β-lactam antibiotics arising during ceftazidime treatment of Pseudomonas aeruginosa infections. Journal of Antimicrobial Chemotherapy 12:363–370
    [Google Scholar]
  7. Knott-Hunziker V, Petursson S, Jayatilake G S, Waley S G, Jaurin B, Grundström T. 1982; Active sites of β-lactamases. The chromosomal β-lactamases of Pseudomonas aeruginosa and Escherichia coli . Biochemical Journal 201:621–627
    [Google Scholar]
  8. Lindberg F, Westman L, Normark S. 1985; Regulatory components in Citrobacter freundii ampC β-lactamase induction. Proceedings of the National Academy of Sciences of the USA 82:4620–4624
    [Google Scholar]
  9. Lindberg F, Normark S. 1986; Contribution of chromosomal β-lactamases to β-lactam resistance in enterobacteria. Reviews of Infectious Diseases 8:3S292–S304
    [Google Scholar]
  10. Livermore D M. 1985; Do β-lactamases ‘trap’ cephalosporins?. Journal of Antimicrobial Chemotherapy 15:511–514
    [Google Scholar]
  11. Livermore D M. 1986; Class I β-lactamase expression in Pseudomonas aeruginosa and cephalosporin resistance. Lancet 1:450
    [Google Scholar]
  12. Nichols W W, Hewinson R G. 1987; Rapid and automated measurement of K m and specific V max values of β- lactamases in bacterial extracts. Journal of Antimicrobial Chemotherapy 19:285–295
    [Google Scholar]
  13. Nordström K, Sykes R B. 1974; Induction kinetics of β-lactamase biosynthesis in Pseudomonas aeruginosa . Antimicrobial Agents and Chemotherapy 6:734–740
    [Google Scholar]
  14. Sanders C C. 1984; Inducible β-lactamases and non-hydrolytic resistance mechanisms. Journal of Antimicrobial Chemotherapy 13:1–3
    [Google Scholar]
  15. Sawai T, Nakajima S, Morohoshi T, Yamagishi S. 1977; Thermolabile repression of cephalosporinase synthesis in Citrobacter freundii . Microbiology and Immunology 21:631–638
    [Google Scholar]
  16. Slack M P E. 1981; Antipseudomonal β-lactams. Journal of Antimicrobial Chemotherapy 8:165–170
    [Google Scholar]
  17. Slack M P E, Pitt T L. 1982; Characterization of cefsulodin-resistant variants of Pseudomonas aeruginosa . Journal of Antimicrobial Chemotherapy 9:111–117
    [Google Scholar]
  18. Slack M P E, Nichols W W, West C. 1983; Studies on the mechanisms of cefsulodin resistance in Pseudomonas aeruginosa . Spitzy K H, Karrer K. Proceedings of the thirteenth international congress of chemotherapy, Part 87 : Antibiotic resistance in vitro Verlag H. Egermann; Vienna:40–43
    [Google Scholar]
  19. Wharton C W, Szawelski R J. 1982; Half-time analysis of the integrated Michaelis equation. Simulation and use of the half-time plot and its direct linear variant in the analysis of some α-chymotrypsin-, papain- and fumarase-catalysed reactions. Biochemical Journal 203:351–360
    [Google Scholar]
  20. Williams R J, Livermore D M, Lindridge M A, Said A A, Williams J D. 1984; Mechanisms of beta-lactam resistance in British isolates of Pseudomonas aeruginosa . Journal of Medical Microbiology 17:283–293
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-24-3-263
Loading
/content/journal/jmm/10.1099/00222615-24-3-263
Loading

Data & Media loading...

Most cited Most Cited RSS feed