%0 Journal Article %A Jones, D. M. %A Eldridge, J. %A Fox, A. J. %A Sethi, P. %A Whorwell, P. J. %T Antibody to the Gastric Campylobacter-like Organism (“Campylobacter Pyloridis”)—Clinical Correlations and Distribution in the Normal Population %D 1986 %J Journal of Medical Microbiology, %V 22 %N 1 %P 57-62 %@ 1473-5644 %R https://doi.org/10.1099/00222615-22-1-57 %I Microbiology Society, %X Summary Different cellular proteins of the gastric campylobacter-like organism (GCLO) were shown to be immunogenic for man. Antibodies to GCLO were detected in sera by both complement fixation and enzyme-linked immunoabsorbent assay. Antibody was found in 133 (52%) of 254 patients attending for gastroscopy. There was a high correlation between presence of antibody and a positive GCLO culture from the gastric mucus. Patients with normal endoscopic appearances, duodenal ulcer, duodenitis and oesophagitis had similar prevalences (c. 50%) of antibody. Only patients with endoscopically visible gastritis or gastric ulcer had a higher frequency (c. 80%) of antibody. In a normal population, antibody was uncommon in individuals <20 years old, but the prevalence of antibody increased (to c. 50%) with age. There was little evidence to support an important pathological role for GCLO in disorders of the upper gastrointestinal tract, although the possibility that it may be a co-factor in the pathogenesis of gastric ulcer cannot be excluded. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-22-1-57