RT Journal Article SR Electronic(1) A1 Ketley, J. M. A1 Mitchell, T. J. A1 Haslam, S. C. A1 Stephen, J. A1 Candy, D. C. A. A1 Burdon, D. W.YR 1986 T1 Sporogenesis and Toxin a Production by Clostridium Difficile JF Journal of Medical Microbiology, VO 22 IS 1 SP 33 OP 38 DO https://doi.org/10.1099/00222615-22-1-33 PB Microbiology Society, SN 1473-5644, AB Summary The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-22-1-33