%0 Journal Article %A Saxena, A. %A Chugh, Shashi %A Vinayak, V. K. %T Antibody-Dependent Macrophage-Mediated Cytotoxicity Against Entamoeba Histolytica %D 1986 %J Journal of Medical Microbiology, %V 22 %N 1 %P 17-21 %@ 1473-5644 %R https://doi.org/10.1099/00222615-22-1-17 %I Microbiology Society, %X Summary Interactions between trophozoites of Entamoeba histolytica and peritoneal exudate macrophages from unsensitised and antigen-sensitised animals were studied in vitro. Normal macrophages killed trophozoites to some extent. This killing capacity was enhanced by prior sensitisation of the animals with specific antigen. Incorporation of anti-amoebic antiserum in the amoeba-macrophage mixture greatly enhanced the killing capacity of macrophages. Fraction one (F-I) of a crude amoebic extract was most effective in enhancing the cytotoxicity of macrophages by prior sensitisation and anti-F-I serum was the most effective antiserum. The cytotoxicity-inducing capacity of the immune serum resided in the IgG but not in the IgM fraction. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-22-1-17