The role of in the pathogenesis of acute appendicitis was studied in 135 patients in four patient groups: normal (17); phlegmonous appendicitis (17); gangrenous appendicitis (75); and septic complications of appendicitis (26). Aerobic and anaerobic bacteria were isolated from all groups and members of the ‘ group’ were the most common anaerobic isolates. The rate of isolation of was similar from normal and inflamed appendices but was significantly higher from those with septic complications (p<0·01). Antibodies against were demonstrated in patients of all groups and occurred with similar frequencies in patients with normal and inflamed appendices but at a significantly higher rate in those with septic complications (p<0·01). Whereas patients in this latter group showed IgM-antibody responses to only, those with acute appendicitis had IgM antibodies against a wide range of organisms of the ‘ group’ which suggests that does not play a significant role in acute appendicitis but may be a major cause of its septic complications.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error