1887

Abstract

Summary

Cross-reactivity in a delayed-type hypersensitivity (DH) response was studied in mice immunised with live A and B. Extensive cross-reactions outside the serogroup limits were observed. The ability of DH cross-reacting and non-cross-reacting sonicates to generate activated macrophages was studied in mice immunised 3 months earlier with B. Whereas DH cross-reacting sonicate generated activated macrophages the non-cross-reacting sonicate did not. To determine whether infections due to diarrhoea-causing salmonellae generated cross-reactive cell-mediated immune responses against enteric fever-causing organisms, similar reverse experiments were performed in mice immunised with A sonicate generated both effector responses, i.e., DH and activated macrophages.

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/content/journal/jmm/10.1099/00222615-21-3-233
1986-05-01
2022-01-23
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