Mixed infections with three species and seven other bacterial species were studied in a subcutaneous abscess model in mice. Fifteen isolates (eight , four , and three ) and one isolate each of , Group A β-haemolytic streptococcus, and were studied. Electronmicrographs showed the presence of a thin mucopolysaccharide wall before and after inoculation into mice in 12 isolates which included all of 11 isolates that induced subcutaneous abscesses. After co-inoculation of isolates with other species and selective therapy with antimicrobial agents, and were found to be of equal or greater importance in abscess induction than were isolates, while isolates were found to be more important than Group A streptococci and Mutual enhancement of the numbers of organisms in mixed infections was observed with spp. and or spp. Suppression of spp. was noticed only when they were co-inoculated with Group A streptococci. The additive or synergistic capabilities of species highlighted their potential pathogenicity in infection.


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