RT Journal Article SR Electronic(1) A1 Silva, C. L. A1 Fazioli, Raquel A.YR 1985 T1 Role of the Fungal Cell Wall in The Granulomatous Response of Mice to the Agents of Chromomycosis JF Journal of Medical Microbiology, VO 20 IS 3 SP 299 OP 305 DO https://doi.org/10.1099/00222615-20-3-299 PB Microbiology Society, SN 1473-5644, AB Summary Mice were given, intraperitoneally, inocula of a cell-wall preparation and fractions thereof from Fonsecaea pedrosoi, F. compactum, Cladosporium carrioni and Phialophora verrucosum. Large doses of cell-wall preparation, with or without trypsin treatment, produced a pronounced loss of body weight, a granulomatous reaction and, sometimes, death. After extraction of the cell wall preparation with IN NaOH, three fractions were obtained: an alkali-insoluble fraction 1; an alkali-soluble acid-insoluble fraction 2; and an alkali- and acid-soluble fraction 3. Intravenous administration showed that only fraction 1 induced a granulomatous reaction and death in mice., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-20-3-299