1887

Abstract

Summary

Existing models of infection are semi-quantitative and do not allow continuous observations to be made on individual animals. We have used the inflammatory response in the footpad as an indirect measure of the number of yeast cells in a localised lesion. infection of the footpad has been used in series of experiments in which changes in yeast-cell numbers in the local lesion have been compared with the degree of footpad oedema. Studies in animals treated with cyclophosphamide or amphotericin have confirmed that paw oedema parallels yeast-cell numbers in the local lesion. This quantitative approach will be helpful in the study of localised infection with and other fungi and in the evaluation of antifungal agents.

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/content/journal/jmm/10.1099/00222615-20-3-283
1985-12-01
2024-04-24
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References

  1. Giger D. K., Domer J. E., McQuitty J. T. 1978; Experimental murine candidiasis: Pathological and immune responses to cutaneous inoculation with Candida albicans.. Infection and Immunity 19:499–509
    [Google Scholar]
  2. Gray D. F., Jennings P. A. 1955; Allergy in experimental mouse tuberculosis. American Review Tuberculosis 72:171–195
    [Google Scholar]
  3. Miller T. E., Ormrod D. 1980; The anti-inflammatory activity of Perna canaliculus (N.Z. green lipped mussel). New Zealand Medical Journal 92:187–193
    [Google Scholar]
  4. Ormrod D. J., Cawley S., Miller T. E. 1984; Extended immunosuppression with cyclophosphamide using controlled-release polymeric implants (bone cement). International Journal of Immunopharmacology (in press)
    [Google Scholar]
  5. Pearsall N. N., Lagunoff D. 1974; Immunological responses to Candida albicans I. Mouse-thigh lesion as a model for experimental candidiasis. Infection and Immunity 9:999–1002
    [Google Scholar]
  6. Poor A. H., Cutler J. E. 1981; Analysis of an in vivo model to study the interaction of host factors with Candida albicans. Infection and Immunity 31:1104–1109
    [Google Scholar]
  7. Ray T. L., Wuepper K. D. 1976; Experimental cutaneous candidiasis in rodents. The Journal of Investigative Dermatology 66:29–33
    [Google Scholar]
  8. Sohnle P. G., Frank M. M., Kirkpatrick C. H. 1976; Mechanisms involved in elimination of organisms from experimental cutaneous Candida albicans infections in guinea pigs. The Journal of Immunology 117:523–530
    [Google Scholar]
  9. Winter C. A., Risley E. A., Nuss G. W. 1962; Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 111:544–547
    [Google Scholar]
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