1887

Abstract

Summary

The effect of pretreatment of denture acrylic with chlorhexidine gluconate on the subsequent adherence of GDH 2346 was measured Adherence was significantly reduced by pretreatment with chlorhexidine; maximal inhibition was achieved by incubation at room temperature for 30 min in 2% chlorhexidine. Inhibition of adherence was greatest when the organisms were grown in conditions that enhanced adherence the most, i.e., growth to stationary phase in high concentrations of galactose and sucrose. Yeasts grown in high concentrations of galactose, which were the most adherent to acrylic, were also the most sensitive to the fungicidal action of chlorhexidine gluconate, whereas those grown in a low concentration of glucose were the least adherent and also the most resistant. Adherence to acrylic of seven strains of isolated from active infections (I strains) and grown in medium containing 500 mm sucrose was significantly higher than that of four strains obtained from asymptomatic carriers (C strains). A spectrum of adherence values was obtained when various yeasts other than were tested.

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1985-08-01
2024-04-18
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References

  1. Bonesvoll P., , Olsen I. 1974; Influence of teeth, plaque and dentures on the retention of chlorhexidine in the human oral cavity. Journal of Clinical Periodontology 1:214–221
    [Google Scholar]
  2. Budtz-Jörgensen E., Löe H. 1972; Chlorhexidine as a denture disinfectant in the treatment of denture stomatitis. Scandinavian Journal of Dental Research 80:457–464
    [Google Scholar]
  3. Budtz-Jörgensen E., Stenderup A., Brabowski M. 1975; An epidemiologic study of yeasts in elderly denture wearers. Community Dentistry and Oral Epidemiology 3:115–119
    [Google Scholar]
  4. Davies A. 1973; The mode of action of chlorhexidine. Journal of Periodontal Research 8: Supplement 1268–75
    [Google Scholar]
  5. Douglas L. J., Houston J. G., McCourtie J. 1981; Adherence of Candida albicans to human buccal epithelial cells after growth on different carbon sources. FEMS Microbiology Letters 12:241–243
    [Google Scholar]
  6. King R. D., Lee J. C., Morris A. L. 1980; Adherence of Candida albicans and other Candida species to mucosal epithelial cells. Infection and Immunity 27:667–674
    [Google Scholar]
  7. Lamb D. J., Martin M. V. 1983; An in vitro and in vivo study of the effect of incorporation of chlorhexidine into acrylic resin plates upon the growth of Candida albicans. Biomaterials 4:205–209
    [Google Scholar]
  8. Langslet A., Olsen I., Lie S. O., Lakken P. 1974; Chlorhexidine treatment of oral candidiasis in seriously diseased children. Acta Paediatrica Scandinavica 63:809–811
    [Google Scholar]
  9. Lodder J. 1970 The yeasts, a taxonomic study. , 2nd edn. North Holland, Amsterdam: p 1385
    [Google Scholar]
  10. McCourtie J., Douglas L. J. 1981; Relationship between cell surface composition of Candida albicans and adherence to acrylic after growth on different carbon sources. Infection and Immunity 32:1234–1241
    [Google Scholar]
  11. McCourtie J., Douglas L. J. 1984; Relationship between cell surface composition, adherence and virulence of Candida albicans. Infection and Immunity 45:6–12
    [Google Scholar]
  12. Odds F. C. 1979 Candida and Candidosis. Leicester University Press; Leicester:
    [Google Scholar]
  13. Olsen I. 1975a; Denture stomatitis—Effects of chlorhexidine and amphotericin B on the mycotic flora. Acta Odontologica Scandinavica, 3341–46
    [Google Scholar]
  14. Olsen I. 1975b; Denture stomatitis—The clinical effects of chlorhexidine and amphotericin B. Acta Odontologica Scandinavica 33:47–52
    [Google Scholar]
  15. Samaranayake L. P., MacFarlane T. W. 1980; An in vitro study of the adherence of Candida albicans to acrylic surfaces. Archives of Oral Biology 25:603–609
    [Google Scholar]
  16. Shakir B. S., Martin M. V., Smith C. J. 1983; Relative effectiveness of various yeasts, Candida spp. and Torulopsis glabrata for inducing palatal infection in the Wistar rat. Archives or Oral Biology, 28:1069–1071
    [Google Scholar]
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