resistant to kanamycin in one household and, in another family, to nalidixic acid, is described. Resistance of this organism to these drugs is uncommon. Some individuals within each family excreted sensitive strains of the shigella. There was no history of previous exposure to either drug and the source of the resistant strains is unknown. As far as we know these strains neither arose from nor spread to the community. Kanamycin-resistance was determined by a transferable factor; no transfer of nalidixic acid-resistance could be demonstrated. The supplanting of the prevailing sensitive strains by new drug-resistant strains of is unexplained in both families.


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