In hamsters a single inoculum of BHK 21 cells chronically infected with rubella virus formed a tumour and stimulated antibody response to the virus. Haemagglutinationinhibition and titration by fluorescent staining were equally sensitive as tests for antibody. The sera with higher HI titre were, when conjugated with fluorescein isothiocyanate (FITC), suitable for immunofluorescent staining.

My thanks are due to Professor K. McCarthy, Department of Bacteriology, University of Liverpool, for kindly supplying the BHK 21 cells chronically infected with rubella virus; to Professor K. B. Fraser for his help and advice; to Dr J. H. Elwood of the Department of Social and Preventive Medicine, The Queen's University of Belfast, for the statistical work, and to Miss Lesley Rusk for technical assistance.

The study was supported by a grant from the National Fund for Research into Crippling Diseases.


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