The diffusible haemolysin of is highly cytotoxic to chick embryo cell cultures, but has no effect on monkey kidney and mouse embryo cell cultures. The cytotoxic effects are specific, as they can be neutralised by specific antisera. Culture fluids from non-haemolytic strains of are non-cytotoxic. The haemolytic activity is thermolabile, but cytotoxicity is thermostable. The antibodies prepared against heated or unheated haemolysins prevent cytotoxicity, but haemolytic activity is neutralised only by antisera prepared against unheated haemolysin. Fraction A of haemolysin is non-haemolytic and non-cytotoxic, whereas fraction B is non-haemolytic but is cytotoxic.

The haemolytic and cytotoxic factors of appear, therefore, not to be identical.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error