1887

Abstract

Summary

Heated spores (80°C, 10 min) of strain CB 1002 isolated from a fatal case of necrotising enterocolitis in a human neonate were inoculated into ligated intestinal loops prepared in young conventional guinea pigs. Necropsy findings 18 h later included congestion, patchy haemorrhage of the intestinal mucosa and bacteraemia. No abnormalities were observed in control loops given inocula of inactivated spores (heated at 100°C for 10 min) or TYG 6 medium. The results suggest that vascular lesions are produced by in the intestine of young conventional guinea pigs.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-19-3-351
1985-06-01
2024-11-11
Loading full text...

Full text loading...

/deliver/fulltext/jmm/19/3/medmicro-19-3-351.html?itemId=/content/journal/jmm/10.1099/00222615-19-3-351&mimeType=html&fmt=ahah

References

  1. Brefort G, Sebald M. 1977; Recherche et identification des anaérobies en bactériologie courtante. Revue du Praticien 27:248–254
    [Google Scholar]
  2. Brown E G, Sweet A Y. 1982; Neonatal necrotizing enterocolitis. Pediatrie Clinics of North America 29:1149–1170
    [Google Scholar]
  3. Cummins C S, Johnson J L. 1971; Taxonomy of the Clostridia: wall composition and DNA homologies in Clostridium butyricum and other butyric acid-producing Clostridia. Journal of General Microbiology 67:33–46
    [Google Scholar]
  4. Duncan C L, Sugiyama H, Strong D H. 1968; Rabbit ileal loop response to strains of Clostridium perfringens. Journal of Bacteriology 95:1560–1566
    [Google Scholar]
  5. Howard F M, Bradley J M, Flynn D M, Noone P, Szawatkowski M. 1977; Outbreak of necrotising enterocolitis caused by Clostridium butyricum. Lancet 2:1099–1102
    [Google Scholar]
  6. Kliegman R M. 1979; Neonatal necrotizing enterocolitis: implications for an infectious disease. Pediatrie Clinics of North America 26:327–344
    [Google Scholar]
  7. Kosloske A M, Ulrich J A, Hoffman H. 1978; Fulminant necrotising enterocolitis associated with Clostridia. Lancet 2:1014–1016
    [Google Scholar]
  8. Kosloske A M, Ulrich J A. 1980; A bacteriologic basis for the clinical presentations of necrotizing enterocolitis. Journal of Pediatrie Surgery 15:558–564
    [Google Scholar]
  9. Labbe R G. 1981; Enterotoxin formation by Clostridium perfringens type A in a defined medium. Applied and Environmental Microbiology 41:315–317
    [Google Scholar]
  10. Laverdière M, Robert A, Chicoine R, Salet D, Rosenfeld R. 1978; Clostridia in necrotising enterocolitis. Lancet 2:377
    [Google Scholar]
  11. Lawrence G, Bates J, Gaul A. 1982; Pathogenesis of neonatal necrotising enterocolitis. Lancet 1:137–139
    [Google Scholar]
  12. Lawrence G W, Bates J. 1983; Pathogenesis of neonatal necrotizing enterocolitis. Lancet 1:540
    [Google Scholar]
  13. Magot M, Carlier J P, Popoff M R. 1983; Identification of Clostridium butyricum and Clostridium beijerinckii by gas-liquid chromatography and sugar fermentation: correlation with DNA homologies and electrophoretic patterns. Journal of General Microbiology 129:2837–2845
    [Google Scholar]
  14. Pedersen P V, Halveg A B, Hansen F H, Christiansen E D, Justesen T, Hogh P. 1976; Necrotising enterocolitis of the newborn—is it gas-gangrene of the bowel?. Lancet 2:715–716
    [Google Scholar]
  15. Popoff M R, Sebald M. 1981; Mise en evidence chez Clostridium butyricum d’un facteur thermostable responsabledu pouvoir pathogèneexperimental. Comptes-Rendusde l’Académie des Sciences de Paris Serie III 292:763–766
    [Google Scholar]
  16. Smith M F, Bordello S P, Clayden G S, Casewell M W. 1980; Clinical and bacteriological findings in necrotizing enterocolitis: a controlled study. Journal of Infection 2:23–31
    [Google Scholar]
  17. Sturm R, Staneck J. L, Stauffer L R, Neblet W W. 1980; Neonatal necrotizing enterocolitis associated with penicillin-resistant, toxigenic Clostridium butyricum. Pediatrics 66:928–931
    [Google Scholar]
  18. Swanson V L, Landing B M. 1980; Pathology. Brown E G, Sweet A Y. Neonatal necrotizing enterocolitis Grune and Stratton; New York:129
    [Google Scholar]
  19. Wilson R, Kanto W P, McCarthy B J, Burton A, Lewin P, Feldman R A. 1982; Age at onset of necrotizing enterocolitis: an epidemiologie analysis. Pediatrie Research 16:82–84
    [Google Scholar]
  20. Wilson R, Del Portillo M, Schmidt E, Feldman R A, Kanto W P. 1983; Risk factors for necrotizing enterocolitis in infants weighing more than 2,000 grams at birth: a case-control study. Pediatrics 71:19–22
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-19-3-351
Loading
/content/journal/jmm/10.1099/00222615-19-3-351
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error