%0 Journal Article %A Bakour, R. %A Balligand, G. %A Laroche, Y. %A Cornelis, G. %A Wauters, G. %T A Simple Adult-Mouse Test for Tissue Invasiveness in Yersinia Enterocolitica Strains of Low Experimental Virulence %D 1985 %J Journal of Medical Microbiology, %V 19 %N 2 %P 237-246 %@ 1473-5644 %R https://doi.org/10.1099/00222615-19-2-237 %I Microbiology Society, %X Summary The virulence of Yersinia enterocolitica depends on the presence of a 70-kilobase plasmid, called the Vwa plasmid. This situation is particularly favourable for studies of the mechanism of pathogenicity, but these are hindered by the lack of a suitable animal test to monitor the virulence of the human-pathogenic strains isolated outside the USA which belong to serogroups O:3, O:9 and O:5,27. We observed that, after oral administration to the mouse, the Vwa-positive strains of these serogroups produce a discrete systemic infection while the Vwa-negative strains do not. We present here a simple mouse-virulence test based on this observation. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-19-2-237