1887

Abstract

Summary

Different colonial morphologies were found among colonies of strain 2996 (B: 2b: P1.2). Examination of cultures, selected on the basis of colony transparency or opacity, revealed that both lipopolysaccharides (LPS) and class-5 outer membrane proteins (OMP) are associated with differences in colonial morphology. Among 13 variants, four LPS variants and two class-5 OMP variants were recognised. All variants were non-fimbriate. The LPS variations were confirmed by immunoprecipitation. In addition to these qualitative variations of LPS, meningococci synthesise LPS of different molecular size depending upon growth phase; larger LPS molecules were found after analysis of stationary-phase cultures than with exponential-phase cultures. These changes did not cause a change in serotyping characteristics. The recognition in this study of intra-strain heterogeneity of meningococcal LPS and class-5 OMPs is important for the understanding of meningococcal pathogenicity. This heterogeneity was also detected in simultaneous isolates from different sites of a patient.

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/content/journal/jmm/10.1099/00222615-19-2-203
1985-04-01
2019-10-22
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-19-2-203
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