1887

Abstract

Summary

The effect of racemic 1-octadecyl-2-methoxy-sn-glycero-3 phosphorylcholine (ET-18-OCH) on the nonspecific resistance of mice to infection with was investigated. Two strains with different virulence were studied and no effect was observed in either case at concentrations of ET-18-OCH up to 100 μg/mouse. However, a concentration of 500 μg/mouse caused decreased resistance to S. , correlating with a depression of carbon clearance. Treatment of macrophages with ET-18-OCH inhibited phagosome-lysosome fusion, but had no effect on zymosan-induced luminol-dependent chemiluminescence. The relationship between the adjuvant and nonspecific anti-infectious activity of ET-18-OCH and other compounds is discussed.

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/content/journal/jmm/10.1099/00222615-19-2-159
1985-04-01
2019-10-20
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-19-2-159
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