1887

Abstract

Summary

The effect of racemic 1-octadecyl-2-methoxy-sn-glycero-3 phosphorylcholine (ET-18-OCH) on the nonspecific resistance of mice to infection with was investigated. Two strains with different virulence were studied and no effect was observed in either case at concentrations of ET-18-OCH up to 100 g/mouse. However, a concentration of 500 g/mouse caused decreased resistance to , correlating with a depression of carbon clearance. Treatment of macrophages with ET-18-OCH inhibited phagosome-lysosome fusion, but had no effect on zymosan-induced luminol-dependent chemiluminescence. The relationship between the adjuvant and nonspecific anti-infectious activity of ET-18-OCH and other compounds is discussed.

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1985-04-01
2022-01-23
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