Susceptibility of to the Bactericidal Activity of Mouse Peritoneal Macrophages and to Hydrogen Peroxide Free

Abstract

Summary

Macrophages from athymic nude mice were infected with to study the intracellular fate of this organism. Using the proportional bactericidal test, we have shown that the viability of . declines rapidly within these macrophages, although results of clearance experiments demonstrate that live and killed organisms are cleared at comparable rates. We have also shown that . is susceptible to the bactericidal effects of hydrogen peroxide and we suggest that hydrogen peroxide generated by macrophages is responsible for the killing of intracellular . .

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1985-02-01
2024-03-29
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