1887

Abstract

Summary

A method is described for producing monovalent and polyvalent vaccines from culture filtrates of . With a single injection, each monovalent vaccine protected mice against lethal intraperitoneal challenge by more than 30 capsular types; and polyvalent vaccines containing 2–12 monovalent components protected against 46–61 of the 77 capsular types of . One vaccine with 12 components, administered in two doses, induced full protection against 71 types and protected half of the mice challenged with the other six types.

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/content/journal/jmm/10.1099/00222615-18-3-413
1984-12-01
2020-01-29
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-18-3-413
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