1887

Abstract

SUMMARY

A method is described for producing monovalent and polyvalent vaccines from culture filtrates of . With a single injection, each monovalent vaccine protected mice against lethal intraperitoneal challenge by more than 30 capsular types; and polyvalent vaccines containing 2–12 monovalent components protected against 46–61 of the 77 capsular types of . One vaccine with 12 components, administered in two doses, induced full protection against 71 types and protected half of the mice challenged with the other six types.

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1984-12-01
2024-04-25
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References

  1. Braude A. I., Ziegler E. J., Douglas H., McCutchan J. A. 1977; Antibody to cell wall glycolipid of gram-negative bacteria: induction of immunity to bacteremia and endotoxemia. Journal of Infectious Diseases 136: Supp 167–173
    [Google Scholar]
  2. Bryan C. S., Reynolds K. L., Brenner E. R. 1983; Analysis of 1,186 episodes of gram-negative bacteremia in non-university hospitals: the effects of antimicrobial therapy.. Reviews of Infectious Diseases 5:629–638
    [Google Scholar]
  3. Casewell M. W. 1982; The role of multiply resistant coliforms in hospital-acquired infection. In Reeves D. S., Geddes A. M. (eds) Recent advances in infection vol 2 Churchill Livingstone; Edinburgh: p 31
    [Google Scholar]
  4. Casewell M. W., Dalton M. T., Webster M., Phillips I. 1977; Gentamicin-resistant Klebsiella aerogenes in a urological ward.. Lancet 2:444–446
    [Google Scholar]
  5. Darrell J. H., Hurdle A. D. F. 1964; Identification and clinical significance of Klebsiella species in chest infections.. Journal of Clinical Pathology 17:617–621
    [Google Scholar]
  6. Davis B., Lilly H. A., Lowbury E. J. L. 1969; Gram-negative bacilli in burns.. Journal of Clinical Pathology 22:634–640
    [Google Scholar]
  7. Duguid J. P., Wilkinson J. F. 1953; The influence of cultural conditions on polysaccharide production by Aerobacteraerogenes. Journal of General Microbiology 9:174–189
    [Google Scholar]
  8. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. 1978; Sequential studies in ankylosing spondylitis: association of Klebsiellapneumoniae with active disease.. Annals Rheumatic Diseases 37:146–151
    [Google Scholar]
  9. Foster W. D., Bragg J. 1962; Biochemical classification of Klebsiella correlated with the severity of the associated disease.. Journal of Clinical Pathology 15:478–481
    [Google Scholar]
  10. Jones R. J. 1970; Passive immunisation against gram-negative bacilli in burns.. British Journal of Experimental Pathology 51:53–58
    [Google Scholar]
  11. Jones R. J. 1971; Early protection by vaccines in burns.. British Journal of Experimental Pathology 52:100–109
    [Google Scholar]
  12. Jones R. J. 1981; Vaccines and antisera against gram-negative bacilli.. Journal of Hospital Infection 2:105–111
    [Google Scholar]
  13. Jones R. J., Roe E. A., Gupta J. L. 1980; Controlled trial of pseudomonas immunoglobulin and vaccine in burn patients.. Lancet 2:1263–1265
    [Google Scholar]
  14. McCabe W. R., Bruins S. C., Craven D. E., Johns M. 1977; Cross-reactive antigens: Their potential for immunization induced immunity to gram-negative bacteria. Journal of Infectious Diseases 136: Supp 161–166
    [Google Scholar]
  15. McHenry M. C., Hawk W. A. 1974; Bacteraemia caused by gram-negative bacilli.. Medical Clinics of North America 58:623–638
    [Google Scholar]
  16. Montgomerie J. Z. 1979; Epidemiology of Klebsiella and hospital-associated infections.. Reviews of Infectious Diseases 1:736–753
    [Google Scholar]
  17. Montgomerie J. Z., Doak P. B., Martin W. J. 1970; Klebsiella in faecal flora of renal transplant patients.. Lancet 2:787–792
    [Google Scholar]
  18. Montgomerie J. Z., Ota J. K. 1980; Klebsiella bacteremia.. Archives of Internal Medicine 140:525–527
    [Google Scholar]
  19. Nakashima I., Nagase F., Kato N. 1977; Adjuvant action of capsular polysaccharide of Klebsiellapneumoniae on antibody response. VI. Site of its action. Zeitschrift fur Immunitatsfors-chung.. Immunobiology 153:204–216
    [Google Scholar]
  20. Palfreyman J. M. 1978; Klebsiella serotyping by counter-current immunoelectrophoresis.. Journal of Hygiene 81:219–226
    [Google Scholar]
  21. Pennington J. E., Menkes E. 1981; Type-specific cross-protective vaccination for gram-negative bacterial pneumonia.. Journal of Infectious Diseases 144:599–603
    [Google Scholar]
  22. Price D. J. E., Sleigh J. D. 1970; Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics.. Lancet 2:1213–1215
    [Google Scholar]
  23. Rennie R. P., Duncan I. B. 1974; Combined biochemical and serological typing of clinical isolates of Klebsiella. Applied Microbiology 28:534–539
    [Google Scholar]
  24. Riottot M. M., Fournier J. M., Jouin H. 1981; Direct evidence for the involvement of capsular polysaccharide in the immunoprotective activity of Klebsiellapneumoniae ribosomal preparations.. Infection and Immunity 31:71–77
    [Google Scholar]
  25. Roe E. A., Jones R. J. 1983; Immunization of burned patients against Pseudomonas aeruginosa infection at Safdarjang Hospital, New Delhi. Reviews of Infectious Diseases 5: Suppl 922–930
    [Google Scholar]
  26. Roe E. A., Jones R. J. Vaccination against Klebsiella aerogenes. Journal of Hygiene (in press)
    [Google Scholar]
  27. Steinhauer B. W., Eickhoff T. C., Kislak J. W., Finland M. 1966; The Klebsiella-Enterobacter-Serra-tia division: Clinical and epidemiological characteristics.. Annals of Internal Medicine 65:1180–1194
    [Google Scholar]
  28. Thomas F. E., Jackson R. T., Melly M. A., Alford R. H. 1977; Sequential hospital-wide outbreaks of resistant serratia and klebsiella infections.. Archives of Internal Medicine 137:581–584
    [Google Scholar]
  29. Umsawasdi T., Middleman E. A., Luna M., Bodey G. P. 1973; Klebsiella bacteremia in cancer patients.. American Journal of Medical Sciences 265:473–482
    [Google Scholar]
  30. Wardle N. 1979; Bacteraemic and endotoxic shock.. British Journal of Hospital Medicine 21:223–231
    [Google Scholar]
  31. Wilkinson J. F., Duguid J. P., Edmunds P. N. 1954; The distribution of polysaccharide production in Aerobacter and Escherichia strains and its relation to antigenic character.. Journal of General Microbiology 11:59–72
    [Google Scholar]
  32. Young L. S. 1980; Immunoprophylaxis and immunotherapy of infection in the compromised host. In Verhoef J., Peterson P. K., Quie P. G. (eds) Infections in the immunocompromised host Elsevier; Amsterdam: p 283
    [Google Scholar]
  33. Young L. S. 1980; Immunoprophylaxis and immunotherapy of infection in the compromised host. In Verhoef J., Peterson P. K., Quie P. G. (eds) Infections in the immunocompromised host Elsevier; Amsterdam: p 283
    [Google Scholar]
  34. Young L. S. 1983; Infectious complications in bone marrow transplant recipients. In Easmon C. S. F., Gaya H. (eds) Second international symposium on infections in the immunocompromised host Academic Press; London: p 27
    [Google Scholar]
  35. Young L. S., Stevens P., Ingram J. 1975; Functional role of antibody against “core” glycolipid of Enterobacteriaceae.. Journal of Clinical Investigation 56:850–861
    [Google Scholar]
  36. Young L. S., Martin W. J., Meyer R. D., Weinstein R. J., Anderson E. T. 1977; Gram-negative rod bacteraemia: microbiologic, immunological and therapeutic considerations.. Annals of Internal Medicine 86:456–471
    [Google Scholar]
  37. Young S. E. J. 1982; Bacteraemia 1975-1980: A survey of cases reported to PHLS Communicable Disease Surveillance Centre.. Journal of Infection 5:19–26
    [Google Scholar]
  38. Ziegler E. J., McCutchan J. A., Fierer J., Glauser M. P., Sadoff J. C., Douglas H., Braude A. I. 1982; Treatment of gram-negative bacteraemia and shock with human antiserum to a mutant Escherichia coli. The New England Journal of Medicine 307:1225–1230
    [Google Scholar]
  39. Zinner S. H., Peter G. 1983; The potential role of cell wall core-glycolipids in the immunoprophy laxis and therapy of gram-negative rod bacteraemia. In Easmon C. S. F., Jeljaszewicz J. (eds) Medical Microbiology vol 2 Immunisation against bacterial disease, Academic Press; London: p 71
    [Google Scholar]
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