Sera obtained from 60 healthy normal subjects were tested for their inhibitory action against four clinical isolates of the group. All the sera inhibited clinical strains of and , 92% of 60 sera inhibited and 62% inhibited . Bacterial inhibition required components of uninactivated serum and was related to the serum concentrations and species of the bacteria. The viable counts of all the strains, except , were significantly reduced in pooled sera from patients with anaerobic systemic infections and from non-infected patients. The bactericidal activity of the sera from infected patients was more pronounced than that of the ‘normal’ sera, on all strains except . These observations may explain in part the predominance of in serious clinical infections involving anaerobes.


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