1887

Abstract

SUMMARY

Eighty-one bacterial strains representing 16 anaerobic species were tested in a sensitive binding assay for uptake of I-labelled human serum proteins. Fifteen of 36 strains (42%) bound significant amounts of human serum albumin (HSA). None of the other bacterial species showed any affinity for HSA. All strains studied were incapable of uptake of human fibrinogen, fibronectin, haptoglobin or aggregated -microglobulin. strain Ra 4 was tested for binding of purified serum albumin from 11 animal species, and showed a binding profile similar to human group-C and -G streptococci, but different from and . Kinetic experiments showed that albumin binding was a rapid displaceable, time-dependent process, that could take place over a wide range of H or salt concentrations. The albumin-binding component of strain Ra 4 was resistant to heat and to periodate treatment, but sensitive to proteolytic enzymes.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-18-2-189
1984-10-01
2022-09-30
Loading full text...

Full text loading...

/deliver/fulltext/jmm/18/2/medmicro-18-2-189.html?itemId=/content/journal/jmm/10.1099/00222615-18-2-189&mimeType=html&fmt=ahah

References

  1. Holdeman L. V., Cato E. P., Moore W. E. C. 1977; Anaerobe laboratory manual. 4th edn Virginia Polytechnic Institute; Blacksburg, VA:
    [Google Scholar]
  2. Kohler W., Prokop O. 1978; Relationship between haptoglobin and Streptococcus pyogenes T 4 antigens. Nature 271:373
    [Google Scholar]
  3. Kronvall G. 1973; A surface component in group, A C and G streptococci with non-immune reactivity for immunoglobulin G. Journal of Immunology 111:1401–1406
    [Google Scholar]
  4. Kronvall G., Myhre E. B., Bjorck L., Berggard I. 1978; Binding of aggregated human β 2-microglobulin to surface protein structure in group A C and G streptococci. Infection and Immunity 22:136–142
    [Google Scholar]
  5. Kronvall G., Schonbeck C., Myhre E. 1979; Fibrinogen binding structures in β-hemolytic streptococci group, A C and G. Comparisons with receptors for IgG and aggregated β 2-microglobulin. Acta Pathologica et Microbiologica Scandinavica Section B 87:303–310
    [Google Scholar]
  6. Kronvall G., Simmons A., Myhre E. B., Jonsson S. 1979; Specific absorption of human serum albumin, immunoglobulin A and immunoglobulin G with selected strains of group A and G streptococci. Infection and Immunity 25:1–10
    [Google Scholar]
  7. Myhre E. B., Kronvall G. 1980; Demonstration of specific binding sites for human serum albumin in group C and G streptococci. Infection and Immunity 27:6–14
    [Google Scholar]
  8. Myhre E. B., Kuusela P. 1983; Binding of human fibronectin to group A C and G streptococci. Infection and Immunity 40:29–34
    [Google Scholar]
  9. Peters T. 1975; Serum albumin. In Putnam F. M. (ed) The plasma proteins, vol 1 2nd edn Academic Press; New York: pp 133–181
    [Google Scholar]
  10. Ofek I., Mirelman D., Sharon N. 1977; Adherence of Escherichia coli to human mucosal cells mediated by mannose receptors. Nature 265:623–625
    [Google Scholar]
  11. Wideback K., Havlicek J., Kronvall G. 1983; Demonstration of a receptor for mouse and human serum albumin in Streptococcus pyogenes . Acta Pathologica et Microbiologica Scandinavica Section B 91:373–382
    [Google Scholar]
  12. Wideback K., Kronvall G. 1982; Surface receptors for serum albumin in group C and G streptococci show three different types of albumin specificity. Infection and Immunity 38:1154–1163
    [Google Scholar]
  13. Wideback K., Seal U. S., Kronvall G. 1982; Receptor in group C and G streptococci detects albumin structures present in mammalian species. Infection and Immunity 36:469–475
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-18-2-189
Loading
/content/journal/jmm/10.1099/00222615-18-2-189
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error