1887

Abstract

SUMMARY

Fimbriae have been demonstrated on strains of that possess agglutinogen 2 (types 1, 2, 3 and 1, 2), but not on those that lack it (types 1,3 and 1). This correlation between fimbriation and the presence of agglutinogen 2 has been found with fresh isolates from children and with laboratory strains that are virulent for mice. If fimbriae enhance the attachment of bacteria to mucosal cells, these findings offer an explanation for the predominance of serotypes 1,2,3 and 1,2 in non-vaccinated communities. The findings also suggest that agglutinogen 3 is not a fimbrial antigen, and because this is an essential component of fully effective whole-cell vaccine, a subcellular vaccine prepared from fimbriae alone may be inadequate.

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/content/journal/jmm/10.1099/00222615-18-1-87
1984-08-01
2022-01-25
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References

  1. Blom J., Hansen G. A., Poulsen F. M. 1983; Morphology of cells and hemagglutinogens of Bordetella species: resolution of substructural units in fimbriae of Bordetella pertussis. Infection and Immunity 42:308–317
    [Google Scholar]
  2. Morse S. I., Morse J. H. 1976; Isolation and properties of the leukocytosis-and lymphocytosis-promoting factor of Bordetella pertussis. Journal of Experimental Medicine 143:1483–1502
    [Google Scholar]
  3. Preston N. W. 1966; Potency tests for pertussis vaccines: doubtful value of intracerebral challenge test in mice. Journal of Pathology and Bacteriology 91:173–179
    [Google Scholar]
  4. Preston N. W. 1970; Technical problems in the laboratory diagnosis and prevention of whooping-cough. Laboratory Practice 19:482–486
    [Google Scholar]
  5. Preston N. W. 1976; Prevalent serotypes of Bordetella pertussis in non-vaccinated communities. Journal of Hygiene 77:85–91
    [Google Scholar]
  6. Preston N. W. 1982; Toxicity of pertussis vaccine. British Medical Journal 284:1817–1818
    [Google Scholar]
  7. Preston N. W. 1983; Whooping cough and pertussis vaccination. British Medical Journal 287:1881–1882
    [Google Scholar]
  8. Preston N. W., Stanbridge T. N. 1972; Efficacy of pertussis vaccines: a brighter horizon. British Medical Journal 3:448–451
    [Google Scholar]
  9. Preston N. W., Surapatana N., Carter E. J. 1982; A reappraisal of serotype factors 4, 5 and 6 of Bordetella pertussis. Journal of Hygiene 88:39–46
    [Google Scholar]
  10. Sawyer W. D., Rosenthal R. S. 1978 Pili and bacterial pathogenicity In Bradley D. E., Raizen E., Fives-Taylor P., Ou J. (eds) Pili Robinson Blackmore, St John’s; Newfoundland: pp 3–21
    [Google Scholar]
  11. Stanbridge T. N., Preston N. W. 1974; Variation of serotype in strains of Bordetella pertussis. Journal of Hygiene 73:305–310
    [Google Scholar]
  12. Wilson G., Miles A., Parker M. T. (Eds) 1983; Topley and Wilson’s Principles of bacteriology. virology and immunity 7th edn Edward Arnold, London: p 347
    [Google Scholar]
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