RT Journal Article SR Electronic(1) A1 Stewart-Tull, D. E. S. A1 Ng, F. K. P. A1 Wardlaw, A. C.YR 1984 T1 Factors affecting the lethality of Campylobacter fetus subspecies jejuni in mice JF Journal of Medical Microbiology, VO 18 IS 1 SP 27 OP 37 DO https://doi.org/10.1099/00222615-18-1-27 PB Microbiology Society, SN 1473-5644, AB SUMMARY Intraperitoneal injection of Campylobacter fetus ss. jejuni into HAM/1CR mice was lethal, but viable counts of bacteria from whole body homogenates, organs and blood indicated that death was not due to sustained bacterial multiplication. Heat-killed organisms (5 x 109 cfu) injected into 7-day-old mice caused death within 24 h and this was shown to be due to endotoxin. Both ferric iron and heterologous lipopolysaccharide enhanced virulence; the LD50 was lowered from 1.8 × 109 cfu to 2.7 × 107 cfu when both were used. Three-day-old or adult animals survived challenge with Campylobacter fetus without clinical symptoms when challenged orally or by intravenous or intraperitoneal routes., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-18-1-27