The importance of K antigens from six strains of Escherichia coli for the interaction with polymorphonuclear leukocytes (PMNL) was studied. The major factor influencing this interaction was the ability of strains to activate complement by the classical route during opsonisation, this process being reduced for most K-positive strains. Interference of K antigens with the functioning of common pili as adhesins of eukaryotic cells was not observed nor a toxic effect of K antigens on PMNL.
Bar-ShavitZ.,
OfekI.,
GoldmanR.,
MirelmanD.,
SharonN.1977; Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi. Biochemical and Biophysical Research Communications 78:455–460
HowardC. J.,
GlynnA. A.1971; The virulence for mice of strains of Escherichia coli related to the effects of K antigens on their resistance to phagocytosis and killing by complement. Immunology 20:767–777
ManganD. F.,
SnyderI. S.1979; Mannose-sensitive stimulation of human leukocyte chemiluminescence by Escherichia coli. Infection and Immunity 26:1014–1019
OfekI.,
BeacheyE. H.,
EisensteinB. I.,
AlkanM. L.,
SharonN.1979; Suppression of bacterial adherence by subminimal inhibitory concentrations of /3-lactam and aminoglycoside antibiotics. Reviews of Infectious Diseases 1:832–837
OkudaJ.,
TakazoeI.1973; Antiphagocytic effects of the capsular structure of a pathogenic strain of Bacteroides melaninogenicus. Bulletin of the Tokyo Dental College 14:99–104
OrskovF.,
OrskovI.,
JannB.,
JannK.1971; Immunoelectrophoretic patterns of extracts from all Escherichia coli O and K antigen test strains: correlation with pathogenicity. Acta Pathologica et Microbiologica Scandinavica, Section B 79:142–152
RobbinsJ. B.,
McCrackenG. H.,
GotschlichE. C.,
OrskovF.,
OrskovI.,
HansonL. A.1974; Escherichia coli K1 capsular polysaccharide associated with neonatal meningitis. New England Journal of Medicine 290:1216–1220
RobertsA. P.,
PhillipsR.1983; The relative importance of the classical and alternative complement pathways in serum bactericidal activity against Escherichia coli. Journal of Medical Microbiology 16:69–74
StevensP.,
ChuC. L.,
YoungL. S.1980; K-l antigen content and the presence of an additional sialic acid-containing antigen among bacteremic K-l Escherichia coli: correlation with susceptibility to opsonophagocytosis. Infection and Immunity 29:1055–1061
TofteR. W.,
PetersonP. K.,
KimY.,
QuieP. G.1980; Influence of serum concentration on opsonization by the classical and alternative complement pathways. Infection and Immunity 27:693–696
Van DijkW. C.,
VerbrughH. A.,
PetersR.,
Van Der TolM. E.,
PetersonP. K.,
VerhoeffJ.1979a; Escherichia coli K antigen in relation to serum-induced lysis and phagocytosis. Journal of Medical Microbiology 12:123–130
Van DijkW. C.,
VerbrughH. A.,
Van der TolM. E.,
PetersR.,
VerhoefJ.1979b; Role of Escherichia coli K capsular antigens during complement activation, C3 fixation and opsonization. Infection and Immunity 25:603–609
Van DijkW. C.,
VerbrughH A.,
Van Der TolM. E.,
PetersR.,
VerhoefJ.1981; Escherichia coli antibodies in opsonisation and protection against infection. Journal of Medical Microbiology 14:381–389
Verweij-van VughtA. M. J. J.,
Van Den BoschJ. F.,
NamavarF.,
SparriusM.,
MaclarenD. M.1983; K antigens of Escherichia coli and virulence in urinary tract infection: studies in mouse model. Journal of Medical Microbiology 16:147–155
WeinsteinR.,
YoungL. S.1978; Phagocytic resistance of Escherichia coli K-l isolates and relationship to virulence. Journal of Clinical Microbiology 8:748–755