1887

Abstract

SUMMARY

Adult female mice were given drinking water containing tobramycin 0.05 mg/ml for a week. After a further day without antibiotic they were inoculated intragastrically with one of three strains of Colonisation of the gastrointestinal tract was judged by culturing faecal pellets. Tobramycin-treated mice differed from untreated animals in that many more of them discharged infected pellets, and their pellets contained 5-> 300 times more campylobacters. Colonisation could be prevented by inoculating the tobramycin-treated animals intragastrically, 24 h before the administration of , with a bacterial suspension prepared from normal faecal pellets. Coliforms, lactobacilli, the two in combination, and anaerobes grown from faecal pellets were not effective in preventing colonisation. Most of the were found in the large intestine of the tobramycin-fed mice. The persistence of colonisation of six dams nursing -infected offspring ranged from 10 to at least 29 weeks.

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/content/journal/jmm/10.1099/00222615-17-1-59
1984-02-01
2022-08-17
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