1887

Abstract

SUMMARY. In tests for IgG antibodies against Coxsackie B viruses in man, the enzyme-linked immunosorbent assay (ELISA) was essentially group-specific and, unlike the type-specific neutralisation test, usually failed to detect rises in antibody titre in paired, acute and convalescent, sera. However, in rabbits immunised against Coxsackie B viruses, ELISA demonstrated both group- and type-specific antibody responses. The lack of type-specificity of ELISA in man is probably because repeated infection with enteroviruses—echoviruses and Coxsackie A as well as Coxsackie B—results in masking of the type-specific antibody response by group-specific antibody.

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/content/journal/jmm/10.1099/00222615-16-4-459
1983-11-01
2020-01-19
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-16-4-459
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