@article{mbs:/content/journal/jmm/10.1099/00222615-16-2-227, author = "Thyagarajan, S. P. and Panchanadam, M. and Subramanian, S. and Sundaravelu, T. and Basheer Ahmed, K. and Madanagopalan, N.", title = "Duration of hepatitis B surface antigenaemia and its correlation with the histopathological and clinical outcome in acute and chronic hepatitis", journal= "Journal of Medical Microbiology", year = "1983", volume = "16", number = "2", pages = "227-231", doi = "https://doi.org/10.1099/00222615-16-2-227", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-16-2-227", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "SUMMARY The persistence of Hepatitis B surface antigen (HBsAg) in 156 patients with histopathologically proven acute viral hepatitis and 27 patients with chronic active hepatitis was assessed and correlated with their clinical and histopathological outcome; 1387 sequential serum samples were tested for HBsAg and its antibody (anti HBs). In the group with acute viral hepatitis, 86% of the patients who recovered, 67% of the patients who deteriorated histopathologically and 67% of the fatal cases carried HBsAg for up to 8 weeks only. While 56% of patients with chronic active hepatitis harboured HBsAg for 13-80 weeks, only 10% of the group with acute viral hepatitis did so. Of patients with chronic active hepatitis 37% deteriorated to cirrhosis and 11% died. Diverse anti-HBs-response patterns are reported and may have clinical significance.", }