1887

Abstract

SUMMARY

We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of in two populations—healthy laboratory workers and patients attending an outpatients’ clinic. When data from the two sources were pooled, it was evident that the presence of HLA-DR3 was associated with carriage, and the presence of HLA-DR2, HLA-DR1 and HLA-Bw35 with lack of carriage. However, since each person may have two antigenic specificities encoded at the HLA-A, the HLA-B, and the HLA-DR loci, the carriage of the organism was analysed for paired combinations of the more frequent phenotypes. For example, the lack of carriage evident with HLA-DR1 was more marked with the DR1-A11 and DR1-B7 combinations while the predisposition towards carriage shown with HLA-DR3 was more marked with the DR3-DR5 combination. The importance of the analysis of antigen combinations is discussed in relation to association of single antigens with carriage of .

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1983-05-01
2024-04-19
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References

  1. Aly R., Shinefield H. I., Strauss W. G., Maibach H. I. 1977; Bacterial adherence to nasal mucosal cells. Infection and Immunity 17:546–549
    [Google Scholar]
  2. Ayliffe G. A. J., Brightwell K. M., Collins B. J., Lowbury E. J. L., Goonatilake P. C. L., Etheridge R. A. 1977; Surveys of hospital infection in the Birmingham Region. 1. Effect of age, sex, length of stay and antibiotic use on nasal carriage of tetracycline-resistant Staphylococcus aureus and on post-operative wound infection. Journal of Hygiene 79:299–314
    [Google Scholar]
  3. Daugharty H. D., Martin R. R., White A. 1969; Reactions of sera and nasal secretions with staphylococcal antigens. Journal of Laboratory and Clinical Medicine 73:1011–1018
    [Google Scholar]
  4. Ehrenkranz N. J. 1966; Nasal rejection of experimentally inoculated Staphylococcus aureus: evidence for an immune reaction in man. Journal of Immunology 96:509–517
    [Google Scholar]
  5. Findlay G. M., Abrahams C. 1946; The incidence of staphylococci in the nose and on the skin of Africans and Europeans in West Africa. Journal of the Royal Army Medical Corps 87:272–274
    [Google Scholar]
  6. Greenberg L. J., Chopyk R. L., Bradley P. W., Lalouel J. M. 1980; Immunogenetics of response to a purified antigen from Group A streptococci. II. Linkage of response to HLA. Immunogenetics 11:161–167
    [Google Scholar]
  7. Greenberg L. J., Gray E. D., Yunis E. J. 1975; Association of HL-A5 and immune responsiveness in vitro to streptococcal antigens. Journal of Experimental Medicine 141:935–943
    [Google Scholar]
  8. Helenius A. 7 others 1978; Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus. Proceedings of the National Academy of Sciences 75:3846–3850
    [Google Scholar]
  9. Hoeksma A., Winkler K. C. 1963; The normal flora of the nose in twins. Acta Leidensia 32:123–133
    [Google Scholar]
  10. Kaslow R. A., Shaw S. 1981; The role of histocompatibility antigens (HLA) in infection. Epidemiologic Reviews 3: edited by Nathanson N., Gordis L. Johns Hopkins University Press; Baltimore MD: pp 90–114
    [Google Scholar]
  11. Kato S., Kimura M., Takakura I., Sakakibara T., Inouye H., Tsuji K. 1978; Possible associations between HLA antigens and the immune responsiveness to attenuated rubella vaccine. Tissue Antigens 11:475–478
    [Google Scholar]
  12. Lehner T., Lamb J. R., Welsh K. L., Batchelor R. J. 1981; Association between HLA-DR antigens and helper cell activity in the control of dental caries. Nature 292:770–772
    [Google Scholar]
  13. Millian S. J., Baldwin J. N., Rheins M. S., Weiser H. H. 1960; Studies on the incidence of coagulase positive staphylococci in a normal unconfined population. American Journal of Public Health 50:791–798
    [Google Scholar]
  14. Nakao Y. 9 others 1980; IgG heavy chain allotypes (Gm) in autoimmune diseases. Clinical and Experimental Immunology 42:20–26
    [Google Scholar]
  15. Noble W. C. 1974; Carriage of S. aureus and beta haemolytic streptococci in relation to race. Acta Dermatovener (Stockholm) 54:403–405
    [Google Scholar]
  16. Noble W. C., Valkenburg H. A., Wolters C. H. L. 1967; Carriage of Staphylococcus aureus in random samples of a normal populations. Journal of Hygiene, Cambridge 65:567–573
    [Google Scholar]
  17. Nose Y., Komori K., Inouye H., Nomura K., Yamamura M., Tsuji K. 1980; Relationship between HLA-D and in vitro and in vivo responsiveness to Candida allergen. Clinical and Experimental Immunology 40:345–350
    [Google Scholar]
  18. Sasazuki Y., Kaneoka H., Nishimura Y., Kaneoka R., Hayama M., Ohkuni H. 1980; An HLA linked immune suppression gene in man. Journal of Experimental Medicine 152:297s–313s
    [Google Scholar]
  19. Van Rood J. J., van Leeuwen A., Keuning J. J., Blusse van Oud Alblas A. 1975; The serological recognition of the human MLC determinants using a modified cytotoxicity technique. Tissue Antigens 5:73–79
    [Google Scholar]
  20. Whittingham S., Mathews J. D., Schanfield M. S., Matthews J.V., Tait B. D., Morris P. J., Mackay I. R. 1980; Interactive effect of Gm allotype and HLA B locus antigens on the human antibody response to a bacterial antigen. Clinical and Experimental Immunology 40:8–15
    [Google Scholar]
  21. Williams R. E. O. 1963; Healthy carriage of Staphylococcus aureus: its prevalence and importance. Bacteriological Reviews 27:56–71
    [Google Scholar]
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