Phagocytosis of Trypanosoma brucei rhodesiense by peritoneal macrophages takes place by seizure of the trypomastigote by either end but usually by the anterior. A lamellar sheath similar to that seen in phagocytosis of the promastigote of Leishmania is observed, but it is smaller and does not proceed to envelop the living parasite. The attached trypomastigote becomes pitted and appears to have been killed and partially destroyed before it is completely engulfed.
AkiyamaH. J.,
HaightR. D.1971; Interaction of Leishmania donovani and hamster peritoneal macrophages. A phase-contrast microscopical study. American Journal of Tropical Medicine and Hygiene 20:539–545
Al-TaqiM.,
MohammedA. H.1981; Scanning electron micrographs showing the early behaviour of macrophages and promastigotes of Leishmania. Transactions of the Royal Society of Tropical Medicine and Hygiene 75:182
AptedF. I. C.,
OrmerodW. E.,
SmylyD. P.,
StronachB. W.,
SzlampE. L.1963; A comparative study of the epidemiology of endemic rhodesian sleeping sickness in different parts of Africa. Journal of Tropical Medicine and Hygiene 66:1–16
HartP. D. A.,
YoungM. R.1975; Interference with normal phagosome-lysosome fusion in macrophages, using ingested yeast cells and suramin. Nature 256:47–49
ListonA. J.,
BakerJ. R.1978; Entry of Trypanosoma (Schizotrypanum) dionisii to macrophages in vitro and its subsequent fate therein. Journal of General Microbiology 107:253–262
LumsdenW. H. R.,
HerbertW. J.1967; Phagocytosis of trypanosomes by mouse peritoneal macrophages. Transactions of the Royal Society of Tropical Medicine and Hygiene 61:142
NogueiraN.,
CohnZ.1976; Trypanosoma cruzi: mechanism of entry and intracellular fate in mammalian cells. Journal of Experimental Medicine 143:1402–1420
PulvertaftR. J. V.,
HoyleG. F.1960; Stages in the life–cycle of Leishmania donovani. Transactions of the Royal Society of Tropical Medicine and Hygiene 54:191–196
StevensD. R.,
MoultonJ. E.1978; Ultrastructural and immunological aspects of the phagocytosis of Trypanosoma brucei by mouse peritoneal macrophages. Infection and Immunity 19:972–982
StuartA. E.,
HabeshawJ. A.,
DavidsonA. E.1978; Phagocytes in vitro. In Handbook of Experimental Immunology 3rd ed., edited by
WeirD. M.
Blackwell; Oxford: pp 31.1–31.30
ZenianA.,
RowlesP.,
GingellD.1979; Scanning electron-microscopic study of the uptake of Leishmania parasites by macrophages. Journal of Cell Science 39:187–199