1887

Abstract

SUMMARY

The importance of K antigens of as virulence factors was studied by comparing groups of mice given either strains of isolated from urinary tract infection in humans or mutant strains differing only in the absence of the K antigen. K antigens proved to be of minor importance for mouse nephropathogeni-city; however, with the exception of the K(A) antigen, they contributed substantially to deaths attributed to more general infection. Possible mechanisms for the virulence of strains with K antigens are discussed in terms of the bactericidal effect of serum and phagocytosis.

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1983-05-01
2024-04-24
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References

  1. Ewetz L., Palmblad J., Thore A. 1979; Quantitation of phagocytosis by luminol chemiluminescence. In Proceedings of the International Symposium on analytical applications of bioluminescence and chemiluminescence edited by Schram E., Stanley P. State Printing and Publishing Inc.; Westgate Village, California: pp 582–588
    [Google Scholar]
  2. Finney D. J. 1964; Statistical methods in biological assay. 2nd ed Griffin, London: p 524
    [Google Scholar]
  3. Freedman L. R. 1979; Interstitial renal inflammation, including pyelonephritis and urinary tract infection. In Strauss and Welt’s Diseases of the Kidney vol II: 3rd ed., edited by Early L. E., Gottschalk C. W. Little Brown and Company; Boston: pp 817–876
    [Google Scholar]
  4. Glynn A. A., Howard C. J. 1970; The sensitivity to complement of strains of Escherichia coli related to their K antigens. Immunology 18:331–346
    [Google Scholar]
  5. Glynn A. A., Brumfitt W., Howard C. J. 1971; K antigens of Escherichia coli and renal involvement in urinary-tract infections. Lancet 1:514–516
    [Google Scholar]
  6. Horwitz M. A., Silverstein S. C. 1980; Influence of the Escherichia coli capsule on complement fixation and on phagocytosis and killing by human phagocytes. Journal of Clinical Investigation 65:82–94
    [Google Scholar]
  7. Howard C. J., Glynn A. A. 1971; The virulence for mice of strains of Escherichia coli related to the effects of K antigens on their resistance to phagocytosis and killing by complement. Immunology 20:767–777
    [Google Scholar]
  8. Kalmanson G. M., Harwick H. J., Turck M., Guze L. B. 1975; Urinary tract infection: Localisation and virulence of Escherichia coli. Lancet 1:134–136
    [Google Scholar]
  9. Kaijser B. 1973; Immunology of Escherichia coli: K antigen and its relation to urinary-tract infection. Journal of Infectious Diseases 127:670–677
    [Google Scholar]
  10. McCabe W. R., Carling P. C., Bruins S., Greely A. 1975; The relation of K antigen to virulence of Escherichia coli. Journal of Infectious Diseases 131:6–10
    [Google Scholar]
  11. Nicholson A. M., Glynn A. A. 1975; Investigation of the effect of K antigen in Escherichia coli urinary tract infections by use of a mouse model. British Journal of Experimental Pathology 56:549–553
    [Google Scholar]
  12. Orskdv F., ørskov I., Jann B., Jann K. 1971; Immunoelectrophoretic patterns of extracts from all Escherichia coli O and K antigen test strains. Correlation with pathogenicity. Acta Pathologica et Microbiologica Scandinavica B 69:142–152
    [Google Scholar]
  13. Rottini G., Dri P., Soranzo M. R., Patriarca P. 1975; Correlation between phagocytic activity and metabolic response of polymorphonuclear leukocytes toward different strains of Escherichia coli. Infection and Immunity 11:417–423
    [Google Scholar]
  14. Scheidegger J. J. 1955; Une micro-methode de l’immuno-electrophorese. International Archives of Allergy and Applied Immunology 7:103–110
    [Google Scholar]
  15. Taylor P. W., Roberts A. P., Gower P. E. 1972; Evaluation of a technique for the estimation of serum bactericidal activity against gram-negative organisms. Medical Laboratory Technology 29:272–279
    [Google Scholar]
  16. Van den Bosch J. F., de Graaff J., MacLaren D. M. 1979; Virulence of Escherichia coli in experimental hematogenous pyelonephritis in mice. Infection and Immunity 25:68–74
    [Google Scholar]
  17. Van den Bosch J. F., Postma P., de Graaff J., MacLaren D. M. 1981; Haemolysis by urinary Escherichia coli and virulence in mice. Journal of Medical Microbiology 14:321–331
    [Google Scholar]
  18. Van den Bosch J. F., Oe P. L., Postma P., de Graaff J., MacLaren D. M., Jansen W. H., Guinee P. A. M. 1980; Virulence of Escherichia coli in acute pyelonephritis, acute cystitis and asymptomatic bacteriuria. Antonie van Leeuwenhoek 46:321–329
    [Google Scholar]
  19. Van Dijk W. C., Verbrugh H. A., Peters R., van der Tol M. E., Peterson P. K., Verhoef J. 1977; Escherichia coli K antigen in relation to serum-induced lysis and phagocytosis. Journal of Medical Microbiology 10:123
    [Google Scholar]
  20. Waalwijk C., van den Bosch J. F., MacLaren D. M., de Graaff J. 1982; Hemolysin plasmid coding for the virulence of a nephropathogenic Escherichia coli strain. Infection and Immunity 35:32–37
    [Google Scholar]
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