1887

Abstract

SUMMARY

An attempt was made to protect rhesus monkeys from dental caries by immunisation with and lipoteichoic acid (LTA). The vaccine composed of gave significant protection against caries, a decrease in the number of , an increase in IgG antibodies and a moderate increase in complement-fixing antibodies to LTA. When LTA was used as immunogen, there was only a small reduction in caries, without any detectable antibodies to LTA and a slight increase in IgG antibodies to cells of . Vaccines of or gave no protection. A combined vaccine of and did not reduce the incidence of caries but the antibody titre to cells of was raised to a level comparable with that in the -immunised monkeys. The results of this investigation in a subhuman primate confirm that immunisation with induces protection against caries, unlike the attempt to immunise with two selected strains of lactobacilli. More studies are required to establish the role of specific serotypes of lactobacilli in the development of dental caries.

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1982-08-01
2024-12-02
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References

  1. Bowden G. H., Hardie J. M. 1971 Anaerobic organisms from the human mouth. Isolation of anaerobes edited by Shapton D. A., Board R. G.SAB Technical Series, No. 5 London:177–206
    [Google Scholar]
  2. Bowen W. H., Cohen B., Cole M. F., Colman G. 1975; Immunisation against dental caries. British Dental Journal 139:45–58
    [Google Scholar]
  3. Bratthall o., Köhler B. 1976; Streptococcus mutans serotypes. Some aspects of their identification, distribution, antigenic shifts, and relationship to caries. Journal of Dental Research 55:C15–C21
    [Google Scholar]
  4. Caldwell J., Challacombe S. J., Lehner T. 1977; A sequential bacteriological and serological investigation of rhesus monkeys immunised against dental caries with Streptococcus mutans. Journal of Medical Microbiology 10:213–224
    [Google Scholar]
  5. Carlsson J., Grahnen H., Jonsson G. 1975; Lactobacilli and streptococci in the mouth of children.. Caries Research 9:333–339
    [Google Scholar]
  6. Challacombe S.J. 1974; Serum complement fixing antibodies in human dental caries. Caries Research 8:84–95
    [Google Scholar]
  7. Challacombe S. J., Russell M. W., Hawkes J. E., Bergmeier L. A., Lehner T. 1978; Passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys. Immunology 35:923–931
    [Google Scholar]
  8. Da vies G. H. G. 1955; The classification of lactobacilli from the human mouth. Journal of General Microbiology 13:481–493
    [Google Scholar]
  9. de Stoppelaar J. D., van Houte J., de Moor C. E. 1967; The presence of dextran forming bacteria resembling Streptococcus bovis and Streptococcus sanguis in human dental plaque. Archives of Oral Biology 12:1199–1202
    [Google Scholar]
  10. Fiedel B. A., Jackson R. W. 1976; Immunogenicity of a purified and carrier-complexed streptococcal lipoteichoic acid. Infection and Immunity 13:1585–1590
    [Google Scholar]
  11. Fitzgerald R. J. 1963; Gnotobiotic contributions to oral microbiology. Journal of Dental Research 42:549–552
    [Google Scholar]
  12. Fitzgerald R. J., Jordan H. V., Archard H. O. 1966; Dental caries in gnotobiotic rats infected with a variety of Lactobacillus acidophilus. Archives of Oral Biology 11:473–476
    [Google Scholar]
  13. Fitzgerald R. J., Keyes P. H. 1960; Demonstration of the etiologic role of streptococci in experimental caries in the hamster. Journal of the American Dental Associaton 61:9–19
    [Google Scholar]
  14. Goadby K. W. 1903 The mycology of the mouth, a textbook of oral bacteria. Longmans; London:
    [Google Scholar]
  15. Green G. E., Dodd M. C. 1956; A study of the bacterial flora of caries-susceptible and caries-immune saliva. Journal of Dental Research 35:572–85
    [Google Scholar]
  16. Hardie J. M. seven others 1977; A longitudinal epidemiological study on dental plaque and the development of dental caries—interim results after two years. Journal of Dental Research 56: special issue C90–C98
    [Google Scholar]
  17. Hayward A. C. 1957; A comparison of Lactobacillus species from human saliva with those from other natural sources. British Dental Journal 102:450–451
    [Google Scholar]
  18. Hayward A. C., Davies G. H. G. 1956; The isolation and classification of lactobacillus strains from Italian saliva samples. British Dental Journal 101:43–46
    [Google Scholar]
  19. Ikeda T., Sandham H. J., Bradley E. L. 1973; Changes in Streptococcus mutans and lactobacilli in plaque in relation to the initiation of dental caries in Negro children. Archives of Oral Biology 18:555–566
    [Google Scholar]
  20. Jay P., Hadley F. P., Bunting R. W. 1936; Observations on relationship of Lactobacillus acidophilus to dental caries in children during experimental feeding of candy. Journal of the American Dental Association 23:846–851
    [Google Scholar]
  21. Knox K. W., Wicken A.J. 1978 Effect of growth conditions on the antigenic components of Streptococcus mutans and lactobacilli. Secretory immunity and infection edited by McGhee J. R., Mestecky J., Babb J. L. Advances in experimental medicine and biology, Plenum Press; New York: 107629–637
    [Google Scholar]
  22. Krasse B., Jordan H. V., Edwardsson S., Svensson I. 1968; The occurrence of certain ‘caries inducing’ streptococci in human dental plaque material with special reference to frequency and activity of caries. Archives of Oral Biology 13:911–918
    [Google Scholar]
  23. Lehner T., Challacombe S. J., Caldwell J. 1975a; An experimental model for immunological studies on dental caries in the rhesus monkey. Archives of Oral Biology 20:299–304
    [Google Scholar]
  24. Lehner T., Challacombe S. J., Caldwell J. 1975b; An immunological investigation into the prevention of caries in deciduous teeth of rhesus monkeys. Archives of Oral Biology 20:305–310
    [Google Scholar]
  25. Lehner T., Challacombe S. J., Caldwell J. 1975c; Immunological and bacteriological basis for vaccination against dental caries in rhesus monkeys. Nature, London 254:517–520
    [Google Scholar]
  26. Lehner T., Challacombe S. J., Wilton J. M. A., Caldwell J. 1976; Cellular and humoral immune responses in vaccination against dental caries in monkeys. Nature, London 264:69–72
    [Google Scholar]
  27. Lehner T., Russell M. W., Scully C. M., Challacombe S.J., Caldwell J. 1979 The role of IgG, IgA and IgM classes of antibodies to Streptococcus mutans in protection against caries in rhesus monkeys. Pathogenic streptococci edited by Parker M. T. Reedbooks; Chertsey, Surrey:215–216
    [Google Scholar]
  28. Michalek S. M., McGhee J. R., Navia J. M., Narrates A. J. 1976; Effective immunity to dental caries: protection of malnourished rats by local injection of Streptococcus mutans. Infection and Immunity 13:782–789
    [Google Scholar]
  29. Rogosa M., Mitchell J. A., Wiseman R. F. 1951; A selective medium for the isolation and enumeration of oral lactobacilli. Journal of Dental Research 30:682–689
    [Google Scholar]
  30. Rolla G. 1980 Role of adherence in the development of dental plaque. The borderland between caries and periodontal disease II edited by Lehner T., Cimasoni G. Academic Press; London:227–240
    [Google Scholar]
  31. Sharpe M. E. 1955; A serological classification of lactobacilli. Journal of General Microbiology 12:107–122
    [Google Scholar]
  32. Sharpe M. E. 1970; Cell wall and cell membrane antigens used in the classification of lactobacilli. International Journal of Systematic Bacteriology 20:509–518
    [Google Scholar]
  33. Smith R., Lehner T. 1981; A radioimmuno assay for serum and gingival crevicular fluid antibodies to a purified protein of Streptococcus mutans. Clinical and Experimental Immunology 43:417–424
    [Google Scholar]
  34. Taubman M. A., Smith D. J. 1974; Effects of local immunization with Streptococcus mutans on induction of salivary immunoglobulin A antibody and experimental dental caries in rats. Infection and Immunity 9:1079–1091
    [Google Scholar]
  35. Wicken A. J., Gibbens J. W., Knox K. W. 1973; Comparative studies on the isolation of membrane lipoteichoic acid from Lactobacillus fermentum. Journal of Bacteriology 113:365–372
    [Google Scholar]
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