1887

Abstract

SUMMARY

During pneumococcal infection of mice, nucleic-acid products, including deoxynucleotides, may be released into the serum from cellular disintegration in at least three organs, the lungs, spleen and liver. The serum, after sterilisation to remove contaminating pneumococci, stimulated multiplication of virulent but not avirulent pneumococci . It also stimulated growth of virulent pneumococci in serum from uninfected animals and could be replaced, at least in part, by certain nucleic-acid degradation products at concentrations found in infected serum. The effects of the serum were lost after dialysis or dilution.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-15-2-163
1982-05-01
2024-04-24
Loading full text...

Full text loading...

/deliver/fulltext/jmm/15/2/medmicro-15-2-163.html?itemId=/content/journal/jmm/10.1099/00222615-15-2-163&mimeType=html&fmt=ahah

References

  1. Braun W., Firshein W. 1967; Biodynamic effects of oligonucleotides. Bact. Rev. 31:83
    [Google Scholar]
  2. Dubos R. J. 1954 Biochemical determinants of microbial diseases (Harvard University monograph in medicine and public health, no. 13). Harvard University Press; Cambridge, Mass:
    [Google Scholar]
  3. Firshein W. 1960; DNA synthesis, respiration and virulence in pneumococci. Ann. N.Y. Acad. Sci. 88:1054
    [Google Scholar]
  4. Firshein W., Zimmerman E.M. 1964; In vitro and in vivo effects of deoxyribonucleic acid degradation products on virulent and avirulent group A streptococci. J. gen. Microbiol. 36:237
    [Google Scholar]
  5. Fiser R. H., Denniston J. C, Rindsig R. B., Beisel W. R. 1971; Effects of acute infection on cholesterogenesis in the rhesus monkey. Proc. Soc. exp. Biol. Med. 138:605
    [Google Scholar]
  6. Guckian J. C. 1973; Role of metabolism in pathogenesis of bacteremia due to Diplococcus pneumoniae in rabbits. J. infect. Dis. 127:1
    [Google Scholar]
  7. Little J. S. 1978; Synthesis, transport and secretion of plasma proteins by the livers of control and Streptococcus pneumoniae infected rats. Infect. Immun. 22:585
    [Google Scholar]
  8. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. J. biol. Chem. 193:265
    [Google Scholar]
  9. Lust G. 1966; Effect of infection on protein and nucleic acid synthesis in mammalian organs and tissues. Fed. Proc 25:1688
    [Google Scholar]
  10. McKee J. J., Braun W. 1962; Effects of enzymatic digests of DNA on staphylococci. Proc. Soc. exp. Biol. Med. 109:166
    [Google Scholar]
  11. Pekarek R. S., Wannemacher R. W., Beisel W. R. 1972; The effect of leukocytic endogenous mediator (LEM) on the tissue distribution of zinc and iron. Proc. Soc. exp. Biol. Med. 140:685
    [Google Scholar]
  12. Schneider W. C. 1957 Determination of nucleic acids in tissues by pentose analysis. In Methods in enzymology 3 edited by Colowick S. P., Kaplan N. O. Academic Press; New York:680
    [Google Scholar]
  13. Skarnes R. C., Watson D. W. 1957; Antimicrobial factors of normal tissues and fluids. Bact. Rev. 21:273
    [Google Scholar]
  14. Thompson W. L., Wannemacher R. W. 1973; Effects of infection with Diplococcus pneumoniae on synthesis of ribonucleic acids in rat liver. Biochem. J. 134:79
    [Google Scholar]
  15. Wannemacher R. W., Powanda M. C, Pekarek R. S., Beisel W. R. 1971; Tissue amino acid flux after exposure of rats to Diplococcus pneumoniae. Infect. Immun. 4:556
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-15-2-163
Loading
/content/journal/jmm/10.1099/00222615-15-2-163
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error