1887

Abstract

SUMMARY

Intranasal inoculation of mice aged 1-6 days with Mount Elgon bat virus produced an acute brain infection and death of all the mice at 5-7 days after inoculation. Virus multiplied in the olfactory bulbs and spread to the midbrain and then hindbrain, reaching titres of 10-10 plaque forming units/g of wet tissue. Fatal disease was prevented by administration of virus antibody after infection, which was then restricted to the olfactory bulbs. Antibody was ineffective when infection was established in the midbrain; it reduced infectivity by about 99% in olfactory bulbs but by only a small fraction in midbrain and hindbrain. The findings may reflect differences in virus maturation and spread, and the accessibility of virus antibody to the olfactory bulbs, midbrain and hindbrain.

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/content/journal/jmm/10.1099/00222615-15-1-131
1982-02-01
2022-09-28
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References

  1. Albrecht P. 1968; Pathogenesis of neurotropic arbovirus infections. Curr. Top. Microbiol. Immun. 43:44
    [Google Scholar]
  2. Della-Porta A. J., Westaway E. G. 1978; A multi-hit model for the neutralization of animal viruses. J. gen. Virol. 38:1
    [Google Scholar]
  3. Hotchin J. 1967; Immune and autoimmune reactions in the pathogenesis of slow virus disease. Curr. Top. Microbiol. Immun. 40:33
    [Google Scholar]
  4. Johnson R. T., Mims C. A. 1968; Pathogenesis of viral infections of the nervous system. New Engl. J. Med. 278:23
    [Google Scholar]
  5. Knudson D. L. 1973; Rhabdoviruses. J. gen. Virol. 20:suppl.105
    [Google Scholar]
  6. Liu O. C, Carter J. E., Sanders B. E., Smith E. C, Hampil B. 1959; A study on serotherapy of poliomyelitis in rhesus monkeys. Br. J. exp. Path. 40:133
    [Google Scholar]
  7. Lodmell D. L., Bell J. F., Moore G. J., Raymond G. H. 1969; Comparative study of abortive and nonabortive rabies in mice. J. inf. Dis. 119:569
    [Google Scholar]
  8. Metselaar D., Williams M. C, Simpson D. I. H., West R., Mutere F. A. 1969; Mount Elgon bat virus: a hitherto undescribed virus from Rhinolophus hildebrandtii eloquens. Arch. ges. Virusforsch. 26:183
    [Google Scholar]
  9. Miyamoto K., Matsumoto S. 1967; Comparative studies between pathogenesis of street and fixed rabies virus. J. exp. Med. 125:447
    [Google Scholar]
  10. Murphy F. A. 1977; Rabies pathogenesis. Brief review. Archs Virol. 54:279
    [Google Scholar]
  11. Murphy F. A., Johnson H. N., Harrison A. K., Shope R. E. 1972; Ultrastructural characterization of a new member of the rhabdovirus group—Klamath virus. Arch. Ges. Virusforsch. 37:323
    [Google Scholar]
  12. Murphy F. A., Shope R. E., Metselaar D., Simpson D. I. H. 1970; Characterization of Mount Elgon bat virus, a new member of the rhabdovirus group. Virology 40:288
    [Google Scholar]
  13. Nathanson N., Cole G. A. 1970; Immunosuppression and experimental virus infection of the nervous system. Adv. Virus Res 16:397
    [Google Scholar]
  14. Patel J. R. 1978; A plaque assay for Mount Elgon bat virus based on intrinsic interference. J. gen. Virol 40:659
    [Google Scholar]
  15. Patel J. R. 1979a; Invasion of mouse brain by Mount Elgon bat virus. J. gen. Virol. 44:587
    [Google Scholar]
  16. Patel J. R. 1979b; The pathogenesis of infection in mouse brain by Mount Elgon bat virus. J. gen. Virol. 45:591
    [Google Scholar]
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