1887

Abstract

Summary.

The quantitative and qualitative changes occurring in the fungal flora of 22 patients with oral and 9 with laryngeal carcinoma were studied during and after radiation therapy. Each patient received 6000 rad of externally applied radiation in divided doses for 5 weeks. The fungal flora was isolated from the patients’ oral cavity and irradiated skin sites during irradiation and 2 weeks and 4–6 months afterwards. The number and types of fungi increased in both groups of patients after the start of irradiation and persisted at high levels for at least 4–6 months after treatment. and were the principal yeasts isolated throughout the period studied but seven other species were also identified. All the yeast isolates were sensitive to miconazole, ketoconazole, amphotericin B and nystatin. Any of these antifungal agents should be appropriate for therapy.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-14-4-457
1981-11-01
2022-05-26
Loading full text...

Full text loading...

/deliver/fulltext/jmm/14/4/medmicro-14-4-457.html?itemId=/content/journal/jmm/10.1099/00222615-14-4-457&mimeType=html&fmt=ahah

References

  1. Al-Tikriti U. 1980; The clinical and microbiological changes in oral mucosa secondary to radiotherapy. M.Med.Sci. thesis University of Sheffield;
    [Google Scholar]
  2. Arendorf T. M., Walker D. M. 1980; The prevalence and intra-oral distribution of Candida albicans in man. Archs. oral Biol 25:1
    [Google Scholar]
  3. Athar M. A., Winner H. I. 1971; The development of resistance by Candida species to polyene antibiotics in vitro. J. med. Microbiol 4:505
    [Google Scholar]
  4. Bannatyne R. M., Cheung R. 1978; Susceptibility of Candida albicans to miconazole. Antimicrob. Agents Chemother 13:1040
    [Google Scholar]
  5. Beumer J., Curtis T., Harrison R. E. 1979; Radiation therapy of the oral cavity: sequelae and management. 1. Head and Neck Surg 1:301
    [Google Scholar]
  6. Bodey G. P. 1975; Infections in cancer patients. Cancer Treat. Rev 2:89
    [Google Scholar]
  7. Boggs D. R., Williams A. F., Howell A. 1961; Thrush in malignant neoplastic disease. Archs intern. Med 107:354
    [Google Scholar]
  8. Budtz-Jorgensen E., Stenderup A., Grabowski M. 1975; An epidemiologic study of yeasts in elderly denture wearers. Commun, dent, oral Epidem 3:115
    [Google Scholar]
  9. Cho S. Y., Choi H. Y. 1979; Opportunistic fungal infection among cancer patients. A 10 year autopsy study. Am. J. clin. Path 72:617
    [Google Scholar]
  10. Cowan S. T. 1974 Cowan and Steel’s Manual for the identification of medical bacterial, 2. Cambridge University Press; Cambridge:111
    [Google Scholar]
  11. Dixon D., Shadomy S., Shadomy H. J., Espinel-Ingroff A., Kerkering T. M. 1978; Comparison of the in vitro antifungal activities of miconazole and a new imidazole, R41, 400. J. infect. Dis 138:245
    [Google Scholar]
  12. Dolan C. T. 1971; A practical approach to the identification of yeast-like organisms. Am. J. din. Path 55:580
    [Google Scholar]
  13. Holbrook W. P., Russell C. 1979; Klebsiella in patients with denture stomatitis. Br. dent. J 146:3
    [Google Scholar]
  14. Martin M. V. 1981; Isolation of oral bacteria. Br. dent. J 150:85
    [Google Scholar]
  15. Martin M. V., and Schneidau J. D. 1970; A simple and reliable assmilation test for the identification of Candida species. Am. J. clin. Path 53:875
    [Google Scholar]
  16. Moody M. R., Young V. M., Morris M. J., Schimpff S. C. 1980; In vitro activities of miconazole, miconazole nitrate and ketoconazole alone and combined with rifampin against Candida spp. and Torulopsis glabrata recovered from cancer patients. Antimicrob. Agents Chemother 17:871
    [Google Scholar]
  17. Moss W. T., Brand W. N., Battifora H. 1973 Radiation oncology; rationale, technique, results, 4. Mosby C. V. St Louis:53–146
    [Google Scholar]
  18. Odds F. C. 1979 Candida and candidosis Leicester University Press; Leicester:81
    [Google Scholar]
  19. Odds F. C., Milne L. J. R., Gentles J. C., Ball E. H. 1980; The activity in vitro and in vivo of a new imidazole antifungal ketoconazole. J. antimicrob. Chemother 6:97
    [Google Scholar]
  20. Robinson J. E. 1976; Characteristics of irradiated soft and hard tissues. J. prosth. Dent 35:549
    [Google Scholar]
  21. Rosenthal L. E., Wilkie B. 1965; The effects of radiotherapy on oral tissues. J. prosth. Dent 15:153
    [Google Scholar]
  22. Shadomy S. 1969; In vitro studies with 5-fluorocytosine. Appl. Microbiol 17:871
    [Google Scholar]
  23. Shannon I. L., Trodahl J. N., Starcke E. N. 1978; Remineralisation of enamel by a saliva substitute designed for use by irradiated patients. Cancer 41:1746
    [Google Scholar]
  24. Shipman B. 1979; Clinical evaluation of oral Candida in cancer chemotherapy patients. J. prosth. Dent 41:63
    [Google Scholar]
  25. Singer C., Kaplan M. H., Armstrong D. 1977; Bacteremia and fungemia complicating neoplastic disease: a study of 364 cases. Am. J. Med 62:731
    [Google Scholar]
  26. Somerville D. A. 1969; The normal flora of the skin in different age groups. Br. J. Derm 81:248
    [Google Scholar]
  27. Walker L. J., Luecke M. R. 1974; The identification of yeasts from clinical material. Proc. Iowa Acad. Sci 81:14
    [Google Scholar]
  28. Walter J. B., Miller H., Bomford C. K. 1979 A short textbook of radiotherapy, 4. Churchill Livingstone; Edinburgh:
    [Google Scholar]
  29. Warnock D. W., Speller D. C. E., Day J. K., Farrell A. J. 1979; Resistogram method for the differentiation of strains of Candida albicans. J. appl. Bact 46:571
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-14-4-457
Loading
/content/journal/jmm/10.1099/00222615-14-4-457
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error