1887

Abstract

Summary.

A solid-phase radioimmunoassay (RIA) for IgG and IgA class antibodies to was developed with serotype L2 as antigen. The assay was sensitive, reproducible and correlated well with an immunofluorescence test (r = 0·85). Serum IgG antibodies were detected in 79% of isolation-positive versus 43% of isolation-negative male patients with urethritis, and serum IgA antibodies in 53% and 21%, respectively. Urethral IgA antibodies, measured from specimens taken for chlamydial isolation, could be detected in 94% and 38%, respectively. From 737 male urethral and 909 female cervical secretions screened for the presence of IgA antibodies, about half were isolation and IgA negative. Only 4% (6/151) of male and 5·4% (2/37) of female isolation-positive specimens were IgA negative. The determination of local IgA antibodies may be used as a screening test in chlamydial genital infections.

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1981-02-01
2022-10-02
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