1887

Abstract

Summary.

Ultracentrifugation was used to separate IgG from IgM in serum samples from children after pertussis vaccination or infection and the fractions were examined by indirect haemagglutination (IHA) and complement-fixation (CF) tests. IHA detected pertussis-specific IgM and IgG but CF detected only IgG which appeared to be of a different subclass from the IHA IgG. The IgM titres were higher after infection than after vaccination but the reverse tended to apply to the IgG titres. Little IgM or CF IgG was detected 5 months after a dose of vaccine, but the IHA IgG persisted longer. Vaccinated children who were subsequently infected showed IgM and CF IgG responses similar to those of unvaccinated, infected children but the IHA IgG titres reached much higher levels.

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/content/journal/jmm/10.1099/00222615-14-1-1
1981-02-01
2022-01-21
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References

  1. Abbott J. D., Preston N. W., Mackay R. I. 1971; Agglutinin response to pertussis vaccination in the child. Br. med. J. 1:86
    [Google Scholar]
  2. Ackers J. P., Dolby J. M. 1972; The antigen of Bordetella pertussis that induces bactericidal antibody and its relationship to protection of mice. J. gen. Microbiol. 70:371
    [Google Scholar]
  3. Bradstreet C. M. P., Tannahill A. J., Edwards J. M. B., Benson P. F. 1972; Detection of Bordetella pertussis antibodies in human sera by complement-fixation and immunofluorescence. J. Hyg., Camb. 70:75
    [Google Scholar]
  4. Cruickshank R., Duguid J. P., Marmion B. P., Swain R. H. A. 1975 Medical microbiology, 12. Churchill Livingston; Edinburgh: 2256
    [Google Scholar]
  5. Dolby J. M., Dolby D. E. 1969; The antibody activities of 19S and 7S fractions from rabbit antisera to Bordetella pertussis . Immunology 16:737
    [Google Scholar]
  6. Dolby J. M., Stephens S. 1973; Pertussis antibodies in the sera of children exposed to Bordetella pertussis by vaccination or infection. J. Hyg., Camb. 71:193
    [Google Scholar]
  7. Macaulay M. E. 1979; The serological diagnosis of whooping cough. J. Hyg., Camb. 83:95
    [Google Scholar]
  8. Stanworth D. R., Turner M. W. 1973 In Handbook of experimental immunology, 2. Weir D. M. Blackwell; Oxford: 110.5
    [Google Scholar]
  9. Thomas G. 1975; Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine. J. Hyg., Camb. 74:233
    [Google Scholar]
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