CORYNEBACTERIUM ULCERANS, a gram-positive bacillus closely related to , has been isolated from cases of acute sore throat, tonsillitis and skin lesions, often from people dealing with cattle (Jebb, 1948; Saxholm, 1951;Tomlinson, 1966). Jayne-Williams and Skerman (1966) and Higgs , (1967) reported as a cause of clinical mastitis in cattle. Subcutaneous injection of a suspension of an overnight culture of a toxigenic strain kills guinea-pigs within 72 h, with changes resembling the effect of diphtheria toxin, except that neutralisation by diphtheria antitoxin is variable (Fox and Frost, 1974; Souckova and Soucek, 1974; Wilson and Miles, 1975).

Petrie and McClean (1934) reported that produced two toxins; one immunologically identical to diphtheria toxin and the other related to the toxin of A close relationship of to is supported by its susceptibility to lysogenisation by the β phage of leading to the production of diphtheria toxin (Maximescu, 1968; Barksdale, 1970). Maximesco (1968) found that and lysogenised by phages produced their own toxin and a toxin identical with that of

The production or action of diphtheria toxin is inhibited by iron (Pappenheimer, 1947; Clarke, 1958), glutamine, ammonium salts, glycamine and prolamine (Kim and Groman, 1965 and ). The absorption of β phage to is inhibited by Tween 80 (Groman and Bobb, 1955). During studies on a toxigenic and bacteriocinogenic strain of (no. 378) we noticed that growth in media containing 0.05-0.5% Tween 80 yielded non-toxic culture supernates. This report described our preliminary investigation of the phenomenon.


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