1887

Abstract

Summary

The effects of tetracycline, chloramphenicol and polymyxin B on growth and protease production by were studied. Tetracycline inhibited protease production at concentrations much lower than those required to cause growth inhibition; the effect was not due to inhibition of protease activity by the antibiotic. In contrast, chloramphenicol and polymyxin B inhibited protease production in direct proportion to the inhibition of growth. Lysozyme-release experiments with washed tetracycline-treated cells indicated that the protease did not accumulate intracellularly. The protease-inhibiting effect of tetracycline might have therapeutic significance if it were found to occur

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/content/journal/jmm/10.1099/00222615-13-2-345
1980-05-01
2022-01-24
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