Skip to content
1887

Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 13, Issue 2

Experimental infection of athymic mice with (Plate XV) No Access

Abstract

Summary

Congenitally athymic nude mice and their hirsute littermates with thymuses were infected with a normally avirulent cyst-producing strain of The nude mice were much less able to cope with the infection. Unlike their hirsute littermates they failed to produce any detectable antibody and apparently allowed faster multiplication of cysts in the brain where the normal inflammatory response was absent. It was concluded that the thymus plays an essential role in the development of immunity to a cyst-producing strain of in mice and in its absence neither humoral nor cellular protective mechanisms can develop.

  • Received:
  • Accepted:
  • Published Online:
© 1980 The Pathological Society of Great Britain and Ireland and Longman Group Ltd.
Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-13-2-307
1980-05-01
2025-01-20
Loading full text...

Full text loading...

References

  1. Buxton D., Reid H. W., Pow I. 1979; Immunosuppression in toxoplasmosis: studies in mice with a Clostridial vaccine and louping-ill virus vaccine. J. comp. Path. Ther 89:375
     [Google Scholar]
  2. Hof H., Emmerling P., Höhne K., Seeliger H. P. R. 1976; Infection of congenitally athymic (nude) mice with Toxoplasma gondii. Annls Microbiol 127b:503
     [Google Scholar]
  3. Huldt G. 1966; Experimental toxoplasmosis. Effect of inoculation of toxoplasma in seropositive rabbits. Acta path, microbiol. scand 68:592
     [Google Scholar]
  4. Jennis F. 1966; A simplified haemagglutination test for toxoplasmosis using pyruvic aldehyde treated cells. Aust. J. exp. Biol. med. Sci 44:317
     [Google Scholar]
  5. Lindberg R. E., Frenkel J. K. 1977; Toxoplasmosis in nude mice. J. Parasit 63:219
     [Google Scholar]
  6. McLeod R., Remington J. S. 1977; Influence of infection with Toxoplasma on macrophage function, and role of macrophages in resistance to Toxoplasma. Am. J. trop. Med. Hyg 26:170
     [Google Scholar]
  7. Masihi K. N., Werner H. 1978; The effect of passively transferred heterologous serum on Toxoplasma gondii in NMRI mice. Influence of the treatment on course of infection and cyst formation. Zentbl. Bakt. ParasitKde I. Abt. Orig 240:135
     [Google Scholar]
/content/journal/jmm/10.1099/00222615-13-2-307
Loading

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error