%0 Journal Article %A Wooley, P. H. %A Ebringer, A. %T CROSSREACTIVITY AS A FACTOR IN THE IMMUNE RESPONSE TO SALMONELLA TYPHIMURIUM IN CBA AND BALB/C MICE %D 1980 %J Journal of Medical Microbiology, %V 13 %N 1 %P 11-17 %@ 1473-5644 %R https://doi.org/10.1099/00222615-13-1-11 %I Microbiology Society, %X SUMMARY The immune response to Salmonella typhimurium was investigated in CB. and BALB/C mice, by an arithmetic Widal agglutination assay. High antibody titres were obtained in CBA and low titres in BALB/C mice after secondary immunisation. A rabbit antiserum raised against S. typhimurium was tested for agglutinating activity after absorption with spleen- and lymph-node cells obtained from unimmunised CBA or BALB/C mice. BALB/C cells consistently removed more anti-S. typhimurium antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique. It is suggested BALBjC mice give a low antibody response because their cell-surface antigens crossreact to a greater degree with S. typhimurium than do CBA cell-surface antigens. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-13-1-11