1887

Abstract

SUMMARY

The immune response to was investigated in CB. and BALB/C mice, by an arithmetic Widal agglutination assay. High antibody titres were obtained in CBA and low titres in BALB/C mice after secondary immunisation.

A rabbit antiserum raised against was tested for agglutinating activity after absorption with spleen- and lymph-node cells obtained from unimmunised CBA or BALB/C mice. BALB/C cells consistently removed more anti- antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique.

It is suggested BALBjC mice give a low antibody response because their cell-surface antigens crossreact to a greater degree with than do CBA cell-surface antigens.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-13-1-11
1980-02-01
2024-04-24
Loading full text...

Full text loading...

/deliver/fulltext/jmm/13/1/medmicro-13-1-11.html?itemId=/content/journal/jmm/10.1099/00222615-13-1-11&mimeType=html&fmt=ahah

References

  1. Deacon N. J., Ebringer A. 1977; Cross-reactivity in the radioimmunoassay of ferritin with cells from high and low responder mice. Biochem. Soc. Trans 5:256
    [Google Scholar]
  2. Di Pauli R. 1972; Genetics of the immune response. I. Differences in the specificity of antibodies to lipopolysaccharides among different strains of mice. J. Immunol 109:394
    [Google Scholar]
  3. Eastwood A. 1927; Bacterial virulence and immunity. J. Hyg., Camb 26:235
    [Google Scholar]
  4. Ebringer A. 1978; The link between genes and disease. New Scient. 79:865
    [Google Scholar]
  5. Ebringer A., Cowling P., Ngwa Suh N., James D.C.O., Ebringer R. W. 1976; Crossreactivity between Klebsiella aerogenes species and B27 lymphocyte antigens as an aetiological factor in ankylosing spondylitis. In HLA and disease edited by Dausset J., Svejgaard A. INSERM: Collague 58:27 INSERM: Paris:
    [Google Scholar]
  6. Ebringer A., Davies D. A. L. 1973; Crossreactivity between synthetic T, G A-L and in transplantation antigens in CBA mice. Nature (New Biol) 241:144
    [Google Scholar]
  7. Ebringer A., Welsh J., Young C. R. 1976; Molecular mimicry as a pathogenetic mechanism in rheumatic fever. Heredity, Lond 37:455
    [Google Scholar]
  8. Gorer P. A., Schutze H. 1938; Genetical studies on immunity in mice. II. Correlation between antibody formation and resistance. J. Hyg., Camb 38:647
    [Google Scholar]
  9. Gowen J. W., Schott R. G. 1933; Genetic predisposition to Bacillus piliformis infection among mice. J. Hyg., Camb 33:370
    [Google Scholar]
  10. Hudson L., Hay F. C. 1976; Practical immunology. Blackwell; Oxford: p 38
    [Google Scholar]
  11. Kaplan M. H., Meyeserian M., Kushner I. 1961; Immunologic studies of heart tissue. IV. Serologic reactions with human heart tissue as revealed by immunofluorescent methods; isoimmune, Wasserman and autoimmune reactions. J. exp. Med 113:17
    [Google Scholar]
  12. Kaufmann F. 1954; Enterobacteriaceae. 2nd ed Munksgaard: Copenhagen:
    [Google Scholar]
  13. Kbwis P. A., Loomis D. 1928; Allergic irritability. IV. The capacity of guinea pigs to produce antibodies as affected by the inheritance and as related to familial resistance to tuberculosis. J. exp. Med. 47:437
    [Google Scholar]
  14. McDevitt H. O., Sela M. 1965; Genetic control of the antibody response. I. Demonstration of determinant specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J. exp. Med 122:517
    [Google Scholar]
  15. Mackie T. J., McCartney J. E. 1953; Handbook of practical bacteriology. 9th ed Livingstone; London: p 275
    [Google Scholar]
  16. Plant J., Glynn A. A. 1974; Natural resistance to Salmonella infection, delayed hypersensitivity and IR genes in different strains of mice. Nature, Lond 248:345
    [Google Scholar]
  17. Rowley D., Jenkin C. R. 1962; Antigenic cross-reaction between host and parasite as a possible cause of pathogenicity. Nature, Lond 193:151
    [Google Scholar]
  18. Sas S. I., Roy R. S., Robson H. G. 1973; Endotoxin sensitivity of inbred mouse strains. Can. J. Microbiol 19:767
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-13-1-11
Loading
/content/journal/jmm/10.1099/00222615-13-1-11
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error