1887

Abstract

SUMMARY

The immune response to was investigated in CB. and BALB/C mice, by an arithmetic Widal agglutination assay. High antibody titres were obtained in CBA and low titres in BALB/C mice after secondary immunisation.

A rabbit antiserum raised against was tested for agglutinating activity after absorption with spleen- and lymph-node cells obtained from unimmunised CBA or BALB/C mice. BALB/C cells consistently removed more anti- antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique.

It is suggested BALBjC mice give a low antibody response because their cell-surface antigens crossreact to a greater degree with than do CBA cell-surface antigens.

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1980-02-01
2022-05-21
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