V, a causative organism of cholera, reaches the intestine by the oral route, where a series of events occurs which leads to induction of disease (Finkelstein, 1975).

Because vibrios do not invade the body and toxin is ultimately responsible for disease, toxin must be released in the intestine. Not much is known about the factors that determine the release of toxin Studies during the past few years have shown that motility and chemotaxis of vibrios and their ability to adhere to intestine are associated with virulence of (LaBrec , 1965; Freter, 1969; Guentzel and Berry, 1975; Freter and Jones, 1976; Schrank and Verwey, 1976; Allweiss , 1977; Bhattacharjee and Srivastava, 1979). By the use of high-resolution transmission and scanning electron microscopy, adherence of vibrios to the intestine has been demonstrated (Patnaik and Ghosh, 1966; Nelson, Clements and Finkelstein 1976). It is not known whether vibrios adhere to the intestinal mucosa to resist removal from the intestine (Dixon, 1960) or whether adherence plays a more specific role in pathogenesis. Is it essential for vibrios to undergo a few cell divisions before elaborating toxin?

The present work was undertaken to study adherence and multiplication of some wild-type and laboratory-derived mutants of in the ligated ileal loops of adult rabbits to assess their role in the pathogenesis of cholera.


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