1887

Abstract

Summary

Several adsorbent materials were evaluated for their ability to bind enterotoxins. Cholestyramine, a strong anion-exchange resin, bound the heat-labile and the heat-stable types of enterotoxin and reduced significantly their effects in some animal models. However, its efficacy in the treatment of diarrhoeic piglets ppeared to be adversely affected by the presence of milk in the alimentary tract.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-12-4-487
1979-11-01
2022-01-29
Loading full text...

Full text loading...

References

  1. Barr M., Arnista E. J. 1957; Adsorption studies on clays III. The adsorption of diphtheria toxin by activated attapulgites, halloysite and kaolin. J. Am. pharm. Ass 46:493
    [Google Scholar]
  2. Bartlett J. G., Chang T. W., Gurwith M., Gorbach S. L., Onderdonk A. B. 1978; Antibiotic-associated pseudomembranous colitis due to toxin producing Clostridia. New Eng. J. Med 298:531
    [Google Scholar]
  3. Berant M., Wagner Y., Cohen N. 1976; Cholestyramine in the management of infantile diarrhoea. J. Pediat. 88:153
    [Google Scholar]
  4. Burbige E. J., Milligan F. D. 1975; Pseudomembranous colitis. Association with antibiotics and therapy with cholestyramine. J. Am. med. Ass 231:1157
    [Google Scholar]
  5. Burgess M. N., Bywater R. J., Cowley C. M., Mullan N. A., Newsome P. M. 1978; Biological evaluation of a methanol-soluble, heat-stable E. coli enterotoxin in infant mice, pigs, rabbits and calves. Infect. Immun 21:526
    [Google Scholar]
  6. Burgess M. N., Cowley C. M., Melling J., Mullan N. A., Newsome P. M. 1979; Assay of the heat-labile enterotoxin of Escherichia coli in infant rabbits. J. med. Microbiol 12:291
    [Google Scholar]
  7. Chang T. W., Onderdonk A. B., Bartlett J. G. 1978; Anion exchange resins in antibiotic-associated colitis. Lancet 2:258
    [Google Scholar]
  8. Dean A. G., Ching Y. C., Williams R. G., Harden L. B. 1972; Test for Escherichia coli enterotoxin using infant mice: application in a study of diarrhea in children in Honolulu. J. infect. Dis 125:407
    [Google Scholar]
  9. Drucker M. M., Ogra P. L., Goldhar J., Neter E. 1977; The effect of attapulgite and charcoal on enterotoxicity of Vibrio cholerae and Escherichia coli enterotoxins in rabbits. Infection 5:211
    [Google Scholar]
  10. DuPont H. L., Sullivan P., Pickering L. K., Haynes G., Ackerman M. S. 1977; Symptomatic treatment of diarrhoea with bismuth subsalicylate among students attending a Mexican University. Gastroenterology 73:715
    [Google Scholar]
  11. Ericsson C. D., Evans D. G., DuPont H. L., Evans D. J., Pickering L. K. 1977; Bismuth subsalicylate inhibits activity of crude toxins of Escherichia coli and Vibrio cholerae. J. infect. Dis 136:693
    [Google Scholar]
  12. Gyles C. L., Zigler M. 1978; The effect of adsorbent and anti-inflammatory drugs on secretion in ligated segments of pig intestine infected with Escherichia coli. Can. J. comp. Med 42:260
    [Google Scholar]
  13. Kohler E. M. 1968; Enterotoxic activity of filtrates of Escherichia coli in young pigs. Am. J. vet. Res 29:2263
    [Google Scholar]
  14. Kohler E. M. 1971; Enterotoxic activity of whole cell lysates of E. coli in young pigs. Am. J. vet. Res 32:731
    [Google Scholar]
  15. Martin G. J. 1955 Ion-exchange and adsorption agents in medicine: the concept of intestinal bionomics London:
    [Google Scholar]
  16. Mitchell I. De G., Tame M. J., Kenworthy R. 1974; Conditions for the production of Escherichia coli enterotoxin in a defined medium. J. med. Microbiol 7:395
    [Google Scholar]
  17. Mullan N. A., Burgess M. N., Newsome P. M. 1978; Characterisation of a partially purified, methanol-soluble, heat-stable Escherichia coli enterotoxin in infant mice. Infect. Immun 19:779
    [Google Scholar]
  18. Nalin D. R., Cash R. A. 1970; Kaolin and cholera. J. Pakistan med. Ass 20:177
    [Google Scholar]
  19. Smith H. W., Gyles C. L. 1970; The relationship between two apparently different enterotoxins produced by enteropathogenic strains of E. coli of porcine origin. J. med. Microbiol 3:403
    [Google Scholar]
  20. Smith H. W., Halls S. 1967; Observations by the ligated intestinal segment and oral inoculation methods on E. coli infections in pigs, calves, lambs and rabbits. J. Path. Bad 93:499
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-12-4-487
Loading

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error