RT Journal Article SR Electronic(1) A1 Thornley, Margaret J. A1 Wilson, D. V. A1 De Hormaeche, Raquel Demarco A1 Oates, J. K. A1 Coombs, R. R. A.YR 1979 T1 Detection Of Gonococcal Antigens In Urine By Radioimmunoassay JF Journal of Medical Microbiology, VO 12 IS 2 SP 161 OP 175 DO https://doi.org/10.1099/00222615-12-2-161 PB Microbiology Society, SN 1473-5644, AB SUMMARY A method of detecting gonococcal antigens by solid-phase radioimmunoassay with radioactively labelled antibody is described. A specificity test has been developed that enables this method to be used to detect gonococcal antigens in urine sediments. When sediments from samples of urine from male patients with gonorrhoea were tested, 31 (74%) of 42 gave positive results, clearly distinguishing them from sediments from urine samples from men with non-specific urethritis, none of which was positive. Ten of 14 urine sediments from urine samples from women with gonorrhoea gave positive results, as did 3 of 18 sediments from urine samples from women patients without gonorrhoea. These experiments demonstrate that gonococcal antigens can be detected in urine by radioimmunoassay; the method could be useful in diagnosis if, after refinement, its sensitivity and specificity were to be increased., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-12-2-161