RT Journal Article SR Electronic(1) A1 Van Dijk, Willemeen C. A1 Verbrugh, H. A. A1 Peters, R. A1 Van Der Tol, Marijke E. A1 Peterson, P. K. A1 Verhoef, J.YR 1979 T1 Escherichia Coli K Antigen in Relation to Serum-Induced Lysis and Phagocytosis JF Journal of Medical Microbiology, VO 12 IS 1 SP 123 OP 130 DO https://doi.org/10.1099/00222615-12-1-123 PB Microbiology Society, SN 1473-5644, AB SUMMARY The presence of capsular polysaccharides (K antigens) and their relation to phagocytosis and sensitivity to the lytic action of serum of 26 strains of E. coli isolated from stools of healthy volunteers and from blood cultures were studied. Four of 12 strains isolated from stool cultures and 12 (86%) of the 14 strains isolated from blood cultures possessed K antigen. Three of the 12 strains isolated from stool cultures and seven of the 14 isolated from blood cultures were resistant to uptake by polymorphonuclear leucocytes; these resistant strains contained large amounts of K antigen. By contrast 10 strains, three with low amounts of K antigen and seven without detectable amounts of K antigen, were readily phagocytosed. Thus it appears that K antigen renders E. coli resistant to phagocytosis. Only four (15%) of the 26 strains were sensitive to serum lysis and there was no correlation between the presence of K antigen and the resistance to serumlysis., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-12-1-123