1887

Abstract

SUMMARY

Known numbers of standard strains of and were inoculated together into surgical incisions in guinea-pigs. Histo-logical and quantitative bacteriological proof is presented that pathogenic synergy occurred with copious pus formation when combinations of subinfective doses of each organism were inoculated. A further series of experiments showed that the amounts and ratios of and in the septic inocula were critical, and that the resultant pus contained equal numbers of both the aerobic and the anaerobic organisms. This model may be suitable for the experimental validation of short-term regimens of prophylactic antibiotics in surgery; the present results seem to have important therapeutic implications.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-11-4-513
1978-11-01
2019-10-14
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-11-4-513
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error