1887

Abstract

SUMMARY

The microbial flora of the jejunal lumen of 28 infants with acute gastroenteritis was compared with that of a group of 10 normal infants. The jejunum of control subjects harboured an “oral” type of flora and in a few instances enterobacteria in small numbers. The concentrations of all but one of the groups of organisms were higher in the patients than in controls, and the differences were of statistical significance for enterobacteria and lactobacilli. In eight subjects, the same pathogen was identified in the jejunum and the stool. In six subjects with rotavirus infection, there were almost no Gram-negative aerobic rods in the jejunum. The possible role of other Gram-negative aerobic rods in producing gastroenteritis is discussed. It is suggested that studies of jejunal flora are of considerable importance in assigning an aetiological role to bacteria in the causation of acute gastroenteritis.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-11-4-433
1978-11-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jmm/11/4/medmicro-11-4-433.html?itemId=/content/journal/jmm/10.1099/00222615-11-4-433&mimeType=html&fmt=ahah

References

  1. Bhat P., Shantakumari S., Rajan D., Mathan V. I., Kapadia C. R., Swarnabai C., Baker S. J. 1972; Bacterial flora of the gastro-intestinal tract in southern Indian control subjects and patients with tropical sprue. Gastroenterology 62:11
    [Google Scholar]
  2. Bishop R. F., Barnes G. L., Townley R. R. W. 1974a; Microbial flora of stomach and small intestine in infantile gastroenteritis. Acta, paediat. scand 63:418
    [Google Scholar]
  3. Bishop R. F., Davidson G. P., Holmes I. H., Ruck B. J. 1974b; Detection of a new virus by electron microscopy of faecal extracts from children with acute gastroenteritis. Lancet 1:149
    [Google Scholar]
  4. Challacombe D. N., Richardson J. M., Erson C. M. 1974a; Bacterial microflora of the upper gastrointestinal tract in infants without diarrhea. Archs Dis. Childh 49:264
    [Google Scholar]
  5. Challacombe D. N., Richardson J. M., Rowe B., Erson C. M. 1974b; Bacterial microflora of the upper gastro-intestinal tract in infants with protracted diarrhea. Archs Dis. Childh 49:270
    [Google Scholar]
  6. Evans D. J. Jr, Evans D. G., Dupont H. L., Ørskov F., Ørskov I. 1977; Pattern of loss of enterotoxigenicity by Escherichia coli isolated from adults with diarrhea: suggestive evidence for an interrelationship with serotype. Infect. Immun 17:105
    [Google Scholar]
  7. Ferrao V., Mavinkurve S. 1977; Pseudomonas aeruginosa in infantile gastroenteritis. Arogya J. Hlth Sci 3:85
    [Google Scholar]
  8. Flewett T. H., Bryden A. S., Davies H. 1974; Diagnostic electron microscopy of the faeces. 1. The viral flora of the faeces as seen by electronmicroscopy. J. clin. Path 27:603
    [Google Scholar]
  9. Flewett T. H., Davies H., Bryden A. S., Robertson M. J. 1974; Diagnostic electronmicroscopy of faeces. II. Acute gastroenteritis associated with reovirus-like particles. J. clin. Path 27:608
    [Google Scholar]
  10. Gorbach S. L., Banwell J. G., Chatterjee B. D., Jacobs B., Sack R. B. 1971; Acute undifferentiated human diarrhea in the tropics. I. Alterations in intestinal microflora. J. clin. Invest 50:881
    [Google Scholar]
  11. Gorbach S. L., Mahalanabis D., Brayton J., Jacobs B., Chatterjee B. D., Neogy K. N. 1970; Intestinal microflora in Asiatic cholera. III. Studies in pediatric cholera. J. Infect. Dis 121:46
    [Google Scholar]
  12. Gordon J. E. 1971; Diarrheal disease of early childhood—worldwide scope of the problem. Ann. N. Y. Acad. Sci 176:9
    [Google Scholar]
  13. Gross R. J., Scotland S. M., Rowe B. 1976; Enterotoxin testing of Escherichia coli causing epidemic infantile enteritis in the U.K. Lancet 1:629
    [Google Scholar]
  14. Guerrant R. L., Moore R. A., Kirschenfield P. M., Sande M. A. 1975; Role of toxigenic and invasive bacteria in acute diarrhea of childhood. N. Engl. J. Med 293:567
    [Google Scholar]
  15. Henderson A., MacLaurin J., Scott J. M. 1969; Pseudomonas in a Glasgow baby unit. Lancet 2:316
    [Google Scholar]
  16. Klipstein F. A., Holdeman L. V., Corcino J. J., Moore W. E. C. 1973; Enterotoxigenic intestinal bacteria in tropical sprue. Ann. intern. Med 79:632
    [Google Scholar]
  17. Koya G., Kosakai N., Fukasawa Y. 1954; Supplementary studies on the multiplication of Escherichia coli 0111: B4 in the intestinal tract of adult volunteers and its relation to manifestation of colienteritis. Jap. J. med. Sci. Biol 7:655
    [Google Scholar]
  18. Middleton P. J., Szymanski M. T., Abbott G. D., Bortolussi R., Hamilton J. R. 1974; Orbivirus acute gastroenteritis of infancy. Lancet 1:1241
    [Google Scholar]
  19. Maiya P. P., Pereira S. M., Mathan M., Bhat P., Albert M. J., Baker S. J. 1977; Etiology of acute gastroenteritis in infancy and early childhood in Southern India. Archs Dis. Childh 52:482
    [Google Scholar]
  20. Olarte J., Ferguson W. W., Henderson N. D., Torregrosa I. 1961; Klebsiella strains isolated from diarrhoeal infants—human volunteer studies. Am. J. Dis. Childh 101:763
    [Google Scholar]
  21. Ørskov F., Ørskov I., Evans D. J. Jr, Sack R. B., Sack D. A., Wadstrom T. 1976; Special Escherichia coli serotypes among enterotoxigenic strains from diarrhea in adults and children. Med. Microbiol. Immun 162:73
    [Google Scholar]
  22. Sack R. B., Hirschhorn N., Brownlee I., Cash R. A., Woodward W. E., Sack D. A. 1975; Enterotoxigenic Escherichia coli associated diarrheal disease in Apache children. N. Engl. J. Med 292:1041
    [Google Scholar]
  23. Sakazaki R., Tamura K., Saito M. 1967; Enteropathogenic Escherichia coli associated with diarrhoea in children and adults. Jap. J. med. Sci. Biol 20:387
    [Google Scholar]
  24. Thomson S. 1955; The role of certain varieties of Bacterium coli in gastroenteritis of babies. J. Hyg., Camb 53:357
    [Google Scholar]
  25. Wadstrom T., Aust-Kettis A., Habte D., Holmgren J., Meeuwisse G., Mollby R., Soderlind O. 1976; Enterotoxin-producing bacteria and parasites in stools of Ethiopian children with diarrheal disease. Archs Dis. Childh 51:865
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-11-4-433
Loading
/content/journal/jmm/10.1099/00222615-11-4-433
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error