1887

Abstract

SUMMARY

A serial study of rotavirus infection in gnotobiotic piglets is described. They were infected when 7 days old and the course of infection was followed for 21 days, by immunofluorescence and histological examinations of the intestinal epithelium and by titration of the virus content of the gut lumen. There appeared to be two stages of recovery of the intestinal wall, the earlier stage involving non-immune mechanisms and the later involving antibody.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-11-3-325
1978-08-01
2024-10-06
Loading full text...

Full text loading...

/deliver/fulltext/jmm/11/3/medmicro-11-3-325.html?itemId=/content/journal/jmm/10.1099/00222615-11-3-325&mimeType=html&fmt=ahah

References

  1. Baintner K., Veress B. 1967; Longitudinal differentiation of the small intestine. Nature, Lond 215:774
    [Google Scholar]
  2. Bishop R. F., Davidson G. P., Holmes I. H., Ruck B. J. 1973; Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis. Lancet 2:1281
    [Google Scholar]
  3. Blandford G., Heath R. B. 1972; Studies on the immune response and pathogenesis of Sendai virus infection of mice. I. The fate of viral antigens. Immunology 22:637
    [Google Scholar]
  4. Davidson G. P., Goller I., Bishop R. F., Townley R. R. W., Holmes I. H., Ruck B. J. 1975; Immunofluorescence in duodenal mucosa of children with acute enteritis due to a new virus. J. Clin. Path 28:263
    [Google Scholar]
  5. Flewett T. H., Bryden A. S., Davies H. 1973; Virus particles in gastroenteritis. Lancet 2:1497
    [Google Scholar]
  6. Flewett T. H., Bryden A. S., Davies H. 1975; Virus diarrhoea in foals and other animals. Vet. Rec 96:477
    [Google Scholar]
  7. Hall G. A., Bridger J. C., Chandler R. L., Woode G. N. 1976; Gnotobiotic piglets experimentally infected with neonatal calf diarrhoea reovirus-like agent (rotavirus). Vet. Path 13:197
    [Google Scholar]
  8. Holmes I. H., Rodger S. M., Schnagl R. D., Ruck B. J., Gust I. D., Bishop R. F., Barnes G. L. 1976; Is lactase the receptor and uncoating enzyme for infantile enteritis (rota) viruses?. Lancet 1:1387
    [Google Scholar]
  9. Hooper B. E., Haelterman E. O. 1969; Lesions of the gastrointestinal tract of pigs infected with transmissible gastroenteritis. Can. J. Comp. Med 33:29
    [Google Scholar]
  10. Lecatsas G. 1974; Virus particles in acute gastroenteritis. Lancet 2:524
    [Google Scholar]
  11. Mebus C. A. 1975; Coronavirus Enteritis In Calves. In Abstracts Of Proc 3rd Int. Congr. Virol Madrid: P 70
    [Google Scholar]
  12. Mebus C. A., Stair E. L., Underdahl N. R., Twiehaus M. J. 1971; Pathology of neonatal calf diarrhea induced by a reo-like virus. Vet. Path 8:490
    [Google Scholar]
  13. Mebus C. A., Underdahl N. R., Rhodes M. B., Twiehaus M. J. 1969; Calf diarrhoea (scours) reproduced with a virus from a field outbreak. Nebraska agric. Exp. Stat. Bull 233:1
    [Google Scholar]
  14. Moon H. W., Kemeny L. J., Lambert G., Stark S. L., Booth G. D. 1975; Age dependent resistance to transmissible gastroenteritis of swine. Iii. Effects of epithelial cell kinetics on coronavirus production and on atrophy of intestinal villi. Vet. Path 12:434
    [Google Scholar]
  15. Moon H. W., Norman J. O., Lambert G. 1973; Age dependent resistance to transmissible gastroenteritis of swine. I. Clinical signs and some mucosal dimensions in small intestine. Can. J. Comp. Med 37:157
    [Google Scholar]
  16. Much D. H., Zajac I. 1972; Purification and characterization of epizootic diarrhea of infant mice virus. Infect. Immun 6:1019
    [Google Scholar]
  17. Pearson G. R., Mcnulty M. S. 1977; Pathological changes in the small intestine of neonatal pigs infected with a pig reovirus-like agent (rotavirus). J. Comp. Path 87:363
    [Google Scholar]
  18. Pensaert M., Haelterman E. O., Burnstein T. 1970; Transmissible gastroenteritis of swine: virus-intestinal cell interactions. I. Immunofluorescence, histopathology and virus production in the small intestine through the course of infection. Arch. Ges. Virusforsch 31:321
    [Google Scholar]
  19. Piazza M., Pane G., Piciotto L., Lombardi D. 1967; Effect on the infectivity of various viruses by the intestinal factor of normal mice which inactivates murine hepatitis virus. Nature, Lond 213:293
    [Google Scholar]
  20. Snodgrass D. R., Angus K. W., Gray E. W. 1977; Rotavirus infection in lambs: pathogenesis and pathology. 1978. Archs Virol 55:263
    [Google Scholar]
  21. Snodgrass D. R., Smith W., Gray E. W., Herring J. A. 1976; A rotavirus in lambs with diarrhoea. Res. vet. Sci 20:113
    [Google Scholar]
  22. Stair E. L., Mebus C. A., Twiehaus M. J., Underdahl N. R. 1973; Neonatal calf diarrhea: electron microscopy of intestines infected with a reovirus-like agent. Vet. Path 10:155
    [Google Scholar]
  23. Tavernor W. D., Trexler P. C., Vaughan L. C., Cox J. E., Jones D. G. C. 1971; The production of gnotobiotic piglets and calves by hysterotomy under general anaesthesia. Vet. Rec 88:10
    [Google Scholar]
  24. Thake D. C., Moon H. W., Lambert G. 1973; Epithelial cell dynamics in transmissible gastroenteritis of neonatal pigs. Vet. Path 10:330
    [Google Scholar]
  25. Turner A. J., Caple I. W., Craven J. A. 1973; Demonstration of virus particles in intestinal contents of calves with diarrhoea. Aust. vet. J 49:544
    [Google Scholar]
  26. Tzipori S., Caple I. W., Butler R. 1976; Isolation of a rotavirus from deer. Vet. Rec 99:398
    [Google Scholar]
  27. Welch A. B., Twiehaus M. J. 1973; Cell culture studies of a neonatal calf diarrhea virus. Can. J. comp. Med 37:287
    [Google Scholar]
  28. Woode G. N., Bridger J. C., Hall G., Dennis M. J. 1974; The isolation of a reovirus-like agent associated with diarrhoea, in colostrum-deprived calves, in Great Britain. Res. vet. Sci 16:102
    [Google Scholar]
  29. Woode G. N., Bridger J., Hall G. A., Jones J. M., Jackson G. 1976; The isolation of reovirus-like agents (rotaviruses) from acute gastroenteritis of piglets. J. med. Microbiol 9:203
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-11-3-325
Loading
/content/journal/jmm/10.1099/00222615-11-3-325
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error