1887

Abstract

SUMMARY

Intradermal injection of type-D epsilon toxin increased the permeability of blood vessels in guinea-pig skin to Evans blue dye by a mechanism not dependent on the release of histamine. The toxin was also found to raise the plasma concentration of cyclic adenosine 3′, 5′-monophosphate in mice. It is concluded that epsilon toxin is an enterotoxin capable of causing widespread damage, after binding to receptor sites on the surface of certain cells, through a mechanism mediated by an adenyl cyclase-cAMP system.

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1978-08-01
2024-04-20
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References

  1. Bullen J. J. 1970; Role of toxins in host-parasite relationships. In Microbial toxins edited by Ajl S. J., Kadis S., Montie T. C. New York and London: vol 1: p 233
    [Google Scholar]
  2. Bullen J. J., Scarisbrick R. 1957; Enterotoxaemia of sheep: experimental reproduction of the disease. J. Path. Bact 73:495
    [Google Scholar]
  3. Buxton D. 1978; The use of an immunoperoxidase technique to investigate by light and electron microscopy the sites of binding of Clostridium welchii type-D epsilon toxin in mice. J. med. Microbiol 11:289
    [Google Scholar]
  4. Buxton D., Morgan K. T. 1976; Studies of lesions produced in the brains of colostrum deprived lambs by Clostridium welchii (Cl. perfringens) type D toxin. J. comp. Path 86:435
    [Google Scholar]
  5. Cochran W. G., Cox G. M. 1957 Experimental designs 2nd ed London:
    [Google Scholar]
  6. Conn E. E., Stumpf P. K. 1972 Outlines of biochemistry, 3rd ed New York:
    [Google Scholar]
  7. Craig J. P. 1965; A permeability factor (toxin) found in cholera stools and culture filtrates and its neutralisation by convalescent cholera sera. Nature, Lond 207:614
    [Google Scholar]
  8. Gardner D. E. 1973a; Pathology of Clostridium welchii type D enterotoxaemia. I. Biochemical and haematological alterations in lambs. J. comp. Path 83:499
    [Google Scholar]
  9. Gardner D. E. 1973b; Pathology of Clostridium welchii type D enterotoxaemia. III. Basis of the hyperglycaemic response. J. comp. Path 83:525
    [Google Scholar]
  10. Gill D. M., Evans D. J., Evans D. G. 1976; Mechanism of activation of adenylate cyclase in vitro by polymyxin-released, heat-labile enterotoxin of Escherichia coli. J. infect. Dis. 133: Suppl S103
    [Google Scholar]
  11. Gordon W. S., Stewart J., Holman H. H., Taylor A. W. 1940; Blood changes and post-mortem findings following intravenous inoculation of sheep with culture filtrates of Clostridium welchii types A, C and D. J. Path. Bact 50:251
    [Google Scholar]
  12. King C. A., van Heyningen W. E. 1973; Deactivation of cholera toxin by a sialidase-resistant monosialosylganglioside. J. infect. Dis 127:639
    [Google Scholar]
  13. O’Brien A. D., Kapral F. A. 1976; Increased cyclic adenosine 3′, 5′-monophosphate content in guinea pig ileum after exposure to Staphylococcus aureus delta toxin. Infect. Immun 13:152
    [Google Scholar]
  14. Rappaport R. S., Sagin J. F., Pierzchala W. A., Bonde G., Rubin B. A., Tint H. 1976; Activation of heat-labile Escherichia coli enterotoxin by trypsin. J. infect. Dis. 133: Suppl S41
    [Google Scholar]
  15. Sandefur P. D., Peterson J. W. 1976; Isolation of skin permeability factors from culture filtrates of Salmonella typhimurium. Infect. Immun. 14:671
    [Google Scholar]
  16. Sharp G. W. G., Hynie S. 1971; Stimulation of intestinal adenyl cyclase by cholera toxin. Nature, Lond 229:266
    [Google Scholar]
  17. Tovey K. C., Oldham K. G., Whelan J. A. M. 1974; A simple direct assay for cyclic AMP in plasma and other biological samples using an improved competitive protein binding technique. Clinica Chim. Acta 56:221
    [Google Scholar]
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