RT Journal Article SR Electronic(1) A1 Namavar, F. A1 De Graaff, J. A1 De With, C. A1 Maclaren, D. M.YR 1978 T1 Novobiocin Resistance and Virulence of Strains of Staphylococcus Saprophyticus Isolated from Urine and Skin JF Journal of Medical Microbiology, VO 11 IS 3 SP 243 OP 248 DO https://doi.org/10.1099/00222615-11-3-243 PB Microbiology Society, SN 1473-5644, AB SUMMARY A method was developed to study virulence of coagulase-negative staphy-lococci. Our results showed that coagulase-negative staphylococci injected into adult mice by the intracerebral route did not give rise to lethal infections, whereas mice aged 2 days were much more susceptible. Novobiocin-resistant strains of Staphylococcus saprophyticus were more virulent than strains of Staphylococcus epidermidis. Strains of S. saprophyticus biotype 3 of Baird-Parker’s classification varied in virulence according to novobiocin sensitivity. In the classification of Kloos and Schleifer, S. saprophyticus biotype 3 can be subdivided into four distinct staphylococcal species, namely S. saprophyticus, S. cohnii, S. haemolyticus and S. warned. S. cohnii and S. saprophyticus were equally virulent for mice aged 2 days, but novobiocin-sensitive S. haemolyticus was less virulent. On epidemiological grounds, however, it would seem that S. saprophyticus has some undefined advantage in invading the urinary tract., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-11-3-243